| 46021 | April 21 | Birth | 1924 – Ira Louvin, American singer-songwriter and mandolin player (The Louvin Brothers) (d. 1965) |
| 46022 | April 21 | Birth | 1925 – Anthony Mason, Australian soldier and judge, 9th Chief Justice of Australia |
| 46023 | April 21 | Birth | 1925 – John Swinton of Kimmerghame, English general and politician, Lord Lieutenant of Berwickshire |
| 46024 | April 21 | Birth | 1926 – Elizabeth II of The United Kingdom |
| 46025 | April 21 | Birth | 1926 – Keith Davey, Canadian businessman and politician (d. 2011) |
| 46026 | April 21 | Birth | 1926 – Robin Ibbs, English lawyer and banker (d. 2014) |
| 46027 | April 21 | Birth | 1926 – Arthur Rowley, English footballer, cricketer, and manager (d. 2002) |
| 46028 | April 21 | Birth | 1927 – Ahmed Arif, Turkish poet and author (d. 1991) |
| 46029 | April 21 | Birth | 1927 – Robert Savoie, Canadian actor and singer (d. 2007) |
| 46030 | April 21 | Birth | 1928 – Jack Evans, Welsh-Canadian ice hockey player and coach (d. 1996) |
| 46031 | April 21 | Birth | 1929 – Barbara Keogh, English actress (d. 2005) |
| 46032 | April 21 | Birth | 1930 – Hilda Hilst, Brazilian author, poet, and playwright (d. 2004) |
| 46033 | April 21 | Birth | 1930 – Silvana Mangano, Italian actress (d. 1989) |
| 46034 | April 21 | Birth | 1930 – Dieter Roth, German-Swiss illustrator and sculptor (d. 1998) |
| 46035 | April 21 | Birth | 1930 – Jack Taylor, English footballer and referee (d. 2012) |
| 46036 | April 21 | Birth | 1932 – Slide Hampton, American trombonist and composer |
| 46037 | April 21 | Birth | 1932 – Elaine May, American actress, director, and screenwriter |
| 46038 | April 21 | Birth | 1932 – Angela Mortimer, English tennis player |
| 46039 | April 21 | Birth | 1933 – Edelmiro Amante, Filipino lawyer and politician (d. 2013) |
| 46040 | April 21 | Birth | 1933 – Easley Blackwood, Jr., American pianist, composer, and educator |
| 46041 | April 21 | Birth | 1933 – Ignatius Zakka I Iwas, Iraqi patriarch (d. 2014) |
| 46042 | April 21 | Birth | 1935 – Robin Dixon, 3rd Baron Glentoran, Irish bobsledder and politician |
| 46043 | April 21 | Birth | 1935 – Charles Grodin, American actor and talk show host |
| 46044 | April 21 | Birth | 1935 – Thomas Kean, American academic and politician, 48th Governor of New Jersey |
| 46045 | April 21 | Birth | 1936 – James Dobson, American evangelist, psychologist, and author, founded Focus on the Family |
| 46046 | April 21 | Birth | 1936 – Reg Fleming, Canadian-American ice hockey player (d. 2009) |
| 46047 | April 21 | Birth | 1936 – Avo Paistik, Estonian pastor, author, illustrator, and painter (d. 2013) |
| 46048 | April 21 | Birth | 1939 – John McCabe, English pianist and composer (d. 2015) |
| 46049 | April 21 | Birth | 1939 – Sister Helen Prejean, American author and activist |
| 46050 | April 21 | Birth | 1940 – Jacques Caron, Canadian ice hockey player and coach |