| 46051 | April 21 | Birth | 1940 – Souleymane Cissé, Malian director, producer, and screenwriter |
| 46052 | April 21 | Birth | 1942 – Laine Kallas, Estonian runner and agronomist |
| 46053 | April 21 | Birth | 1942 – Pierre Lorrain, Canadian lawyer and politician (d. 2004) |
| 46054 | April 21 | Birth | 1943 – Alan Fersht, English chemist and academic |
| 46055 | April 21 | Birth | 1944 – Paul Geremia, American singer-songwriter and guitarist |
| 46056 | April 21 | Birth | 1944 – Adrian Hurley, Australian basketball player and coach |
| 46057 | April 21 | Birth | 1945 – Ian Bruce, English author and academic |
| 46058 | April 21 | Birth | 1945 – Diana Darvey, English actress, singer, and dancer (d. 2000) |
| 46059 | April 21 | Birth | 1945 – Philip Sidney, 2nd Viscount De L'Isle, English soldier |
| 46060 | April 21 | Birth | 1945 – Ronnie Tober, Dutch-American singer |
| 46061 | April 21 | Birth | 1945 – Srinivasaraghavan Venkataraghavan, Indian cricketer and umpire |
| 46062 | April 21 | Birth | 1947 – Barbara Park, American author (d. 2013) |
| 46063 | April 21 | Birth | 1947 – Iggy Pop, American singer-songwriter, producer, and actor (The Stooges and The Trolls) |
| 46064 | April 21 | Birth | 1947 – John Weider, English bass player (Family, The Animals, Johnny Kidd & the Pirates, and Stud) |
| 46065 | April 21 | Birth | 1948 – Gary Condit, American businessman and politician |
| 46066 | April 21 | Birth | 1948 – Paul Davis, American singer-songwriter and pianist (d. 2008) |
| 46067 | April 21 | Birth | 1948 – Dieter Fromm, German runner |
| 46068 | April 21 | Birth | 1948 – Alan West, Baron West of Spithead, English admiral and politician, Minister for Security |
| 46069 | April 21 | Birth | 1949 – Patti LuPone, American actress and singer |
| 46070 | April 21 | Birth | 1950 – Bruce Duperouzel, Australian footballer and cricketer |
| 46071 | April 21 | Birth | 1950 – Shivaji Satam, Indian actor |
| 46072 | April 21 | Birth | 1951 – Tony Danza, American actor and producer |
| 46073 | April 21 | Birth | 1951 – Michael Freedman, American mathematician and academic |
| 46074 | April 21 | Birth | 1951 – Bob Varsha, American sportscaster |
| 46075 | April 21 | Birth | 1951 – Steve Vickers, Canadian ice hockey player |
| 46076 | April 21 | Birth | 1952 – Gerald Early, American author and academic |
| 46077 | April 21 | Birth | 1952 – Cheryl Gillan, Welsh businesswoman and politician, Secretary of State for Wales |
| 46078 | April 21 | Birth | 1953 – Forrest, American-Dutch singer (d. 2013) |
| 46079 | April 21 | Birth | 1953 – Mike Clasper, English businessman |
| 46080 | April 21 | Birth | 1953 – Guy Mongrain, Canadian journalist and game show host |