| 46081 | April 21 | Birth | 1954 – Ebiet G. Ade, Indonesian singer-songwriter and guitarist |
| 46082 | April 21 | Birth | 1954 – James Morrison, American actor, director, producer, and screenwriter |
| 46083 | April 21 | Birth | 1955 – Murathan Mungan, Turkish author, poet, and playwright |
| 46084 | April 21 | Birth | 1955 – Doug Soetaert, Canadian ice hockey player |
| 46085 | April 21 | Birth | 1956 – Peter Kosminsky, English director, producer, and screenwriter |
| 46086 | April 21 | Birth | 1956 – Phillip Longman, German-American demographer and journalist |
| 46087 | April 21 | Birth | 1956 – Nina Temple, English activist |
| 46088 | April 21 | Birth | 1957 – Brutus Beefcake, American wrestler |
| 46089 | April 21 | Birth | 1957 – Hervé Le Tellier, French linguist and author |
| 46090 | April 21 | Birth | 1957 – Jesse Orosco, American baseball player |
| 46091 | April 21 | Birth | 1957 – Herbert Wetterauer, German painter, sculptor, and author |
| 46092 | April 21 | Birth | 1958 – Andie MacDowell, American actress and producer |
| 46093 | April 21 | Birth | 1958 – Yoshito Usui, Japanese illustrator (d. 2009) |
| 46094 | April 21 | Birth | 1958 – Michael Zarnock, American author |
| 46095 | April 21 | Birth | 1959 – Tim Jacobus, American illustrator and painter |
| 46096 | April 21 | Birth | 1959 – Olga Kuragina, Russian pentathlete |
| 46097 | April 21 | Birth | 1959 – Arno Pijpers, Dutch footballer and coach |
| 46098 | April 21 | Birth | 1959 – Robert Smith, English singer-songwriter and guitarist (The Cure, Siouxsie and the Banshees, and The Glove) |
| 46099 | April 21 | Birth | 1960 – Michel Goulet, Canadian ice hockey player and scout |
| 46100 | April 21 | Birth | 1960 – Julius Korir, Kenyan runner |
| 46101 | April 21 | Birth | 1961 – Cathy Cavadini, American voice actress and singer |
| 46102 | April 21 | Birth | 1961 – Ronald Florijn, Dutch rower |
| 46103 | April 21 | Birth | 1961 – Carey Hayes, American screenwriter and producer |
| 46104 | April 21 | Birth | 1961 – Chad Hayes, American actor, producer, and screenwriter |
| 46105 | April 21 | Birth | 1961 – Neale Marmon, English-German footballer, coach, and manager |
| 46106 | April 21 | Birth | 1961 – David Servan-Schreiber, French physician, neuroscientist, and author (d. 2011) |
| 46107 | April 21 | Birth | 1962 – Les Lancaster, American baseball player and coach |
| 46108 | April 21 | Birth | 1962 – Craig Robinson, American basketball player and coach |
| 46109 | April 21 | Birth | 1962 – Aavo Sarap, Estonian footballer and coach |
| 46110 | April 21 | Birth | 1963 – Ken Caminiti, American baseball player (d. 2004) |