| 46381 | April 22 | Birth | 1872 – Princess Margaret of Prussia (d. 1954) |
| 46382 | April 22 | Birth | 1873 – Ellen Glasgow, American author (d. 1945) |
| 46383 | April 22 | Birth | 1876 – Róbert Bárány, Austrian-Swedish otologist and physician, Nobel Prize laureate (d. 1936) |
| 46384 | April 22 | Birth | 1876 – Georg Lurich, Estonian wrestler and strongman (d. 1920) |
| 46385 | April 22 | Birth | 1879 – Bernhard Gregory, Estonian-German chess player (d. 1939) |
| 46386 | April 22 | Birth | 1884 – Otto Rank, Austrian-American psychologist and academic (d. 1939) |
| 46387 | April 22 | Birth | 1886 – Izidor Cankar, Slovenian historian, author, and diplomat (d. 1958) |
| 46388 | April 22 | Birth | 1889 – Richard Glücks, German SS officer (d. 1945) |
| 46389 | April 22 | Birth | 1891 – Laura Gilpin, American photographer (d. 1979) |
| 46390 | April 22 | Birth | 1891 – Vittorio Jano, Italian engineer (d. 1965) |
| 46391 | April 22 | Birth | 1891 – Harold Jeffreys, English mathematician, geophysicist, and astronomer (d. 1989) |
| 46392 | April 22 | Birth | 1891 – Nicola Sacco, Italian-American criminal (d. 1927) |
| 46393 | April 22 | Birth | 1892 – Vernon Johns, American minister and activist (d. 1965) |
| 46394 | April 22 | Birth | 1899 – Vladimir Nabokov, Russian-Swiss entomologist, author, and critic (d. 1977) |
| 46395 | April 22 | Birth | 1904 – J. Robert Oppenheimer, American physicist and academic (d. 1967) |
| 46396 | April 22 | Birth | 1905 – Robert Choquette, American-Canadian author, poet, and diplomat (d. 1991) |
| 46397 | April 22 | Birth | 1906 – Eddie Albert, American actor, singer, and producer (d. 2005) |
| 46398 | April 22 | Birth | 1906 – Eric Fenby, English composer and educator (d. 1997) |
| 46399 | April 22 | Birth | 1906 – Prince Gustaf Adolf, Duke of Västerbotten (d. 1947) |
| 46400 | April 22 | Birth | 1907 – Ivan Yefremov, Russian paleontologist and author (d. 1972) |
| 46401 | April 22 | Birth | 1909 – Rita Levi-Montalcini, Italian neurologist and academic, Nobel Prize laureate (d. 2012) |
| 46402 | April 22 | Birth | 1909 – Indro Montanelli, Italian journalist and historian (d. 2001) |
| 46403 | April 22 | Birth | 1910 – Norman Steenrod, American mathematician and academic (d. 1971) |
| 46404 | April 22 | Birth | 1912 – Kathleen Ferrier, English singer (d. 1953) |
| 46405 | April 22 | Birth | 1912 – Kaneto Shindo, Japanese director, producer, and screenwriter (d. 2012) |
| 46406 | April 22 | Birth | 1914 – Baldev Raj Chopra, Indian director and producer (d. 2008) |
| 46407 | April 22 | Birth | 1914 – Jan de Hartog, Dutch-American author and playwright (d. 2002) |
| 46408 | April 22 | Birth | 1914 – José Quiñones Gonzales, Peruvian soldier and pilot (d. 1941) |
| 46409 | April 22 | Birth | 1914 – Michael Wittmann, German SS officer (d. 1944) |
| 46410 | April 22 | Birth | 1916 – Kanan Devi, Indian actress and singer (d. 1992) |