| 46411 | April 22 | Birth | 1916 – Hanfried Lenz, German mathematician and academic (d. 2013) |
| 46412 | April 22 | Birth | 1916 – Yehudi Menuhin, American-Swiss violinist and conductor (d. 1999) |
| 46413 | April 22 | Birth | 1917 – Yvette Chauviré, French ballerina |
| 46414 | April 22 | Birth | 1917 – Sidney Nolan, Australian painter (d. 1992) |
| 46415 | April 22 | Birth | 1918 – William Jay Smith, American poet and academic (d. 2015) |
| 46416 | April 22 | Birth | 1918 – Mickey Vernon, American baseball player and coach (d. 2008) |
| 46417 | April 22 | Birth | 1919 – Donald J. Cram, American chemist and academic, Nobel Prize laureate (d. 2001) |
| 46418 | April 22 | Birth | 1919 – Carl Lindner, Jr., American businessman and philanthropist (d. 2011) |
| 46419 | April 22 | Birth | 1922 – Richard Diebenkorn, American soldier and painter (d. 1993) |
| 46420 | April 22 | Birth | 1922 – Charles Mingus, American bassist, composer, and bandleader (d. 1979) |
| 46421 | April 22 | Birth | 1922 – Wolf V. Vishniac, American microbiologist and academic (d. 1973) |
| 46422 | April 22 | Birth | 1923 – Avis Bunnage, English actress (d. 1990) |
| 46423 | April 22 | Birth | 1923 – Peter Kane Dufault, American soldier, pilot, and poet (d. 2013) |
| 46424 | April 22 | Birth | 1923 – Bettie Page, American model and actress (d. 2008) |
| 46425 | April 22 | Birth | 1923 – Aaron Spelling, American actor, producer, and screenwriter (d. 2006) |
| 46426 | April 22 | Birth | 1924 – Nam Duck-woo, South Korean politician, 12th Prime Minister of South Korea (d. 2013) |
| 46427 | April 22 | Birth | 1925 – George Cole, English actor (d. 2015) |
| 46428 | April 22 | Birth | 1926 – Charlotte Rae, American actress and singer |
| 46429 | April 22 | Birth | 1926 – James Stirling, Scottish architect, designed the Staatsgalerie Stuttgart and Seeley Historical Library (d. 1992) |
| 46430 | April 22 | Birth | 1927 – Laurel Aitken, Cuban-Jamaican singer (d. 2005) |
| 46431 | April 22 | Birth | 1929 – Michael Atiyah, English-Lebanese mathematician and academic |
| 46432 | April 22 | Birth | 1929 – Robert Wade-Gery, English diplomat, British High Commissioner to India (d. 2015) |
| 46433 | April 22 | Birth | 1930 – Enno Penno, Estonian politician, Prime Minister of Estonia in exile |
| 46434 | April 22 | Birth | 1931 – John Buchanan, Canadian lawyer and politician, 20th Premier of Nova Scotia |
| 46435 | April 22 | Birth | 1931 – Ronald Hynd, English dancer and choreographer |
| 46436 | April 22 | Birth | 1933 – Mark Damon, American actor and producer |
| 46437 | April 22 | Birth | 1933 – Anthony Llewellyn, Welsh-American chemist and astronaut (d. 2013) |
| 46438 | April 22 | Birth | 1934 – Nico Ladenis, Tanzanian-English chef and author |
| 46439 | April 22 | Birth | 1935 – Christopher Ball, English linguist and academic |
| 46440 | April 22 | Birth | 1935 – Paul Chambers, American bassist and composer (Miles Davis Quintet) (d. 1969) |