| 46441 | April 22 | Birth | 1935 – Mario Machado, Chinese-American journalist and actor (d. 2013) |
| 46442 | April 22 | Birth | 1936 – Glen Campbell, American singer-songwriter, guitarist, and actor (The Champs) |
| 46443 | April 22 | Birth | 1936 – Pierre Hétu, Canadian pianist and conductor (d. 1998) |
| 46444 | April 22 | Birth | 1937 – Jack Nicholson, American actor, director, producer, and screenwriter |
| 46445 | April 22 | Birth | 1937 – Jack Nitzsche, American singer-songwriter, pianist, and conductor (Crazy Horse) (d. 2000) |
| 46446 | April 22 | Birth | 1938 – Gani Fawehinmi, Nigerian lawyer and activist (d. 2009) |
| 46447 | April 22 | Birth | 1938 – Issey Miyake, Japanese fashion designer |
| 46448 | April 22 | Birth | 1938 – Adam Raphael, English journalist and author |
| 46449 | April 22 | Birth | 1939 – Mel Carter, American singer and actor |
| 46450 | April 22 | Birth | 1939 – John Chilcot, English civil servant |
| 46451 | April 22 | Birth | 1939 – John Foley, English general and politician, Lieutenant Governor of Guernsey |
| 46452 | April 22 | Birth | 1939 – Ray Guy, Canadian journalist and author (d. 2013) |
| 46453 | April 22 | Birth | 1939 – Jason Miller, American actor and playwright (d. 2001) |
| 46454 | April 22 | Birth | 1939 – Ann Mitchell, English actress |
| 46455 | April 22 | Birth | 1939 – Theodor Waigel, German lawyer and politician, German Federal Minister of Finance |
| 46456 | April 22 | Birth | 1941 – Greville Howard, Baron Howard of Rising, English politician |
| 46457 | April 22 | Birth | 1940 – Marie-José Nat, French actress |
| 46458 | April 22 | Birth | 1942 – Giorgio Agamben, Italian philosopher and academic |
| 46459 | April 22 | Birth | 1942 – Denis Lill, New Zealand-English actor |
| 46460 | April 22 | Birth | 1942 – Mary Prior, English politician, Lord Lieutenant of Bristol |
| 46461 | April 22 | Birth | 1943 – Keith Crisco, American businessman and politician (d. 2014) |
| 46462 | April 22 | Birth | 1943 – Janet Evanovich, American author |
| 46463 | April 22 | Birth | 1943 – Louise Glück, American poet and academic |
| 46464 | April 22 | Birth | 1943 – John Maples, Baron Maples, English lawyer and politician, Shadow Secretary of State for Defence (d. 2012) |
| 46465 | April 22 | Birth | 1944 – Steve Fossett, American businessman, pilot, and sailor (d. 2007) |
| 46466 | April 22 | Birth | 1944 – Doug Jarrett, Canadian ice hockey player (d. 2014) |
| 46467 | April 22 | Birth | 1944 – Joshua Rifkin, American conductor and musicologist |
| 46468 | April 22 | Birth | 1945 – Gopalkrishna Gandhi, Indian civil servant and politician, 22nd Governor of West Bengal |
| 46469 | April 22 | Birth | 1945 – Demetrio Stratos, Egyptian-Italian singer-songwriter (Area) (d. 1979) |
| 46470 | April 22 | Birth | 1946 – Steven L. Bennett, American captain and pilot, Medal of Honor recipient (d. 1972) |