| 46501 | April 22 | Birth | 1959 – Ryan Stiles, American-Canadian actor and producer |
| 46502 | April 22 | Birth | 1959 – Musa Uzunlar, Turkish actor |
| 46503 | April 22 | Birth | 1960 – Lloyd Honeyghan, Jamaican-English boxer |
| 46504 | April 22 | Birth | 1960 – Mart Laar, Estonian historian and politician, 9th Prime Minister of Estonia |
| 46505 | April 22 | Birth | 1960 – Gary Rhodes, English chef and author |
| 46506 | April 22 | Birth | 1960 – Randall L. Stephenson, American businessman |
| 46507 | April 22 | Birth | 1960 – Tatiana Thumbtzen, American actress, model, and dancer |
| 46508 | April 22 | Birth | 1961 – Alo Mattiisen, Estonian composer (d. 1996) |
| 46509 | April 22 | Birth | 1961 – Ann McKechin, Scottish lawyer and politician, Shadow Secretary of State for Scotland |
| 46510 | April 22 | Birth | 1961 – Dewey Nicks, American photographer and director |
| 46511 | April 22 | Birth | 1962 – Jeff Minter, English video game designer |
| 46512 | April 22 | Birth | 1962 – Danièle Sauvageau, Canadian ice hockey player and coach |
| 46513 | April 22 | Birth | 1963 – Rosalind Gill, English sociologist and academic |
| 46514 | April 22 | Birth | 1963 – Sean Lock, English comedian and actor |
| 46515 | April 22 | Birth | 1963 – Magnús Ver Magnússon, Icelandic weightlifter and strongman |
| 46516 | April 22 | Birth | 1964 – Estelle Asmodelle, Australian model and actress |
| 46517 | April 22 | Birth | 1964 – Chris Makepeace, Canadian actor and director |
| 46518 | April 22 | Birth | 1965 – Lauri Hendler, American actress |
| 46519 | April 22 | Birth | 1965 – Fikret Kuşkan, Turkish actor |
| 46520 | April 22 | Birth | 1965 – Miguel Leal, Portuguese footballer and manager |
| 46521 | April 22 | Birth | 1965 – Peter Zezel, Canadian ice hockey and soccer player (d. 2009) |
| 46522 | April 22 | Birth | 1966 – Dana Barron, American actress and producer |
| 46523 | April 22 | Birth | 1966 – Kimberley Dahme, American singer-songwriter and guitarist (Boston) |
| 46524 | April 22 | Birth | 1966 – Fletcher Dragge, American guitarist and producer (Pennywise) |
| 46525 | April 22 | Birth | 1966 – Mariana Levy, Mexican actress and singer (d. 2005) |
| 46526 | April 22 | Birth | 1966 – Mickey Morandini, American baseball player and manager |
| 46527 | April 22 | Birth | 1966 – Jeffrey Dean Morgan, American actor |
| 46528 | April 22 | Birth | 1967 – Sheryl Lee, German-American actress |
| 46529 | April 22 | Birth | 1967 – David J. C. MacKay, English physicist, engineer, and academic |
| 46530 | April 22 | Birth | 1967 – Sherri Shepherd, American comedian, actress, and talk show host |