| 46591 | April 22 | Birth | 1983 – Sam W. Heads, English-American entomologist and palaeontologist |
| 46592 | April 22 | Birth | 1983 – Jos Hooiveld, Dutch footballer |
| 46593 | April 22 | Birth | 1983 – Matt Jones, American football player |
| 46594 | April 22 | Birth | 1983 – Vangelis Mantzios, Greek footballer |
| 46595 | April 22 | Birth | 1984 – Amelle Berrabah, English singer-songwriter (Sugababes) |
| 46596 | April 22 | Birth | 1984 – Michelle Ryan, English actress |
| 46597 | April 22 | Birth | 1985 – Matt Ballinger, American singer and actor (Dream Street) |
| 46598 | April 22 | Birth | 1985 – Blake Fitzpatrick, American director and screenwriter |
| 46599 | April 22 | Birth | 1985 – Pablo Cáceres Rodríguez, Uruguayan footballer |
| 46600 | April 22 | Birth | 1985 – Kseniya Simonova, Ukrainian painter and sculptor |
| 46601 | April 22 | Birth | 1986 – Amber Heard, American actress and producer |
| 46602 | April 22 | Birth | 1986 – Marshawn Lynch, American football player |
| 46603 | April 22 | Birth | 1986 – Dušan Šakota, Serbian-Greek basketball player |
| 46604 | April 22 | Birth | 1987 – BC Jean, American singer-songwriter and actress |
| 46605 | April 22 | Birth | 1987 – David Luiz, Brazilian footballer |
| 46606 | April 22 | Birth | 1987 – David Mateos, Spanish footballer |
| 46607 | April 22 | Birth | 1987 – John Obi Mikel, Nigerian footballer |
| 46608 | April 22 | Birth | 1988 – James Ross, American drag queen performer |
| 46609 | April 22 | Birth | 1988 – Amadou Samb, Senegalese footballer |
| 46610 | April 22 | Birth | 1989 – DeJuan Blair, American basketball player |
| 46611 | April 22 | Birth | 1989 – Jasper Cillessen, Dutch footballer |
| 46612 | April 22 | Birth | 1989 – Thomas James Longley, English actor and model |
| 46613 | April 22 | Birth | 1990 – Óscar González, Mexican boxer (d. 2014) |
| 46614 | April 22 | Birth | 1990 – Machine Gun Kelly, American rapper |
| 46615 | April 22 | Birth | 1990 – Eve Muirhead, Scottish curler |
| 46616 | April 22 | Birth | 1990 – Jade Windley, English tennis player |
| 46617 | April 22 | Birth | 1991 – Braydon Smith, Australian boxer (d. 2015) |
| 46618 | April 22 | Birth | 1992 – Joc Pederson, American baseball player |
| 46619 | April 22 | Birth | 1992 – Kenny Stills, American football player |
| 46620 | April 22 | Birth | 1992 – Rolene Strauss, South African model, Miss World 2014 |