| 46621 | April 22 | Birth | 1992 – Joonas Vaino, Estonian basketball player |
| 46622 | April 22 | Birth | 1992 – Robin van Helsum, Dutch criminal |
| 46623 | April 22 | Birth | 1993 – Ryu Hwa-young, South Korean rapper, dancer, and actress (T-ara) |
| 46624 | April 22 | Birth | 1995 – Victoria Rodríguez, Mexican tennis player |
| 46625 | April 22 | Birth | 1997 – Jekalyn Carr, American singer-songwriter |
| 46626 | April 22 | Death | 296 – Pope Caius |
| 46627 | April 22 | Death | 536 – Pope Agapetus I |
| 46628 | April 22 | Death | 591 – Peter III of Raqqa |
| 46629 | April 22 | Death | 613 – Saint Theodore of Sykeon |
| 46630 | April 22 | Death | 1616 – Miguel de Cervantes, Spanish novelist, poet, and playwright (b. 1547) |
| 46631 | April 22 | Death | 1672 – Georg Stiernhielm, Swedish linguist and poet (b. 1598) |
| 46632 | April 22 | Death | 1699 – Hans Erasmus Aßmann, German poet (b. 1646) |
| 46633 | April 22 | Death | 1758 – Antoine de Jussieu, French botanist and physician (b. 1686) |
| 46634 | April 22 | Death | 1806 – Pierre-Charles Villeneuve, French admiral (b. 1763) |
| 46635 | April 22 | Death | 1821 – Gregory V of Constantinople, Greek patriarch and saint (b. 1746) |
| 46636 | April 22 | Death | 1833 – Richard Trevithick, English engineer and explorer (b. 1771) |
| 46637 | April 22 | Death | 1850 – Friedrich Robert Faehlmann, Estonian philologist and physician (b. 1798) |
| 46638 | April 22 | Death | 1854 – Nicolás Bravo, Mexican general and politician, 11th President of Mexico (b. 1786) |
| 46639 | April 22 | Death | 1877 – James P. Kirkwood, Scottish-American engineer (b. 1807) |
| 46640 | April 22 | Death | 1892 – Édouard Lalo, French violinist and composer (b. 1823) |
| 46641 | April 22 | Death | 1893 – Chaim Aronson, Lithuanian businessman and author (b. 1825) |
| 46642 | April 22 | Death | 1894 – Kostas Krystallis, Greek author and poet (b. 1868) |
| 46643 | April 22 | Death | 1896 – Thomas Meik, English engineer, founded Halcrow Group (b. 1812) |
| 46644 | April 22 | Death | 1908 – Henry Campbell-Bannerman, Scottish-English merchant and politician, Prime Minister of the United Kingdom (b. 1836) |
| 46645 | April 22 | Death | 1925 – André Caplet, French composer and conductor (b. 1878) |
| 46646 | April 22 | Death | 1929 – Henry Lerolle, French painter and art collector (b. 1848) |
| 46647 | April 22 | Death | 1932 – Ferenc Oslay, Hungarian-Slovene historian and author (b. 1883) |
| 46648 | April 22 | Death | 1933 – Henry Royce, English engineer and businessman, co-founded Rolls-Royce Limited (b. 1863) |
| 46649 | April 22 | Death | 1944 – Nikolaos Roussen, Greek captain (b. 1913) |
| 46650 | April 22 | Death | 1945 – Wilhelm Cauer, German mathematician and academic (b. 1900) |