| 48331 | April 27 | Event | 629 – Shahrbaraz is crowned as king of the Sasanian Empire. |
| 48332 | April 27 | Event | 711 – Islamic conquest of Hispania: Moorish troops led by Tariq ibn Ziyad land at Gibraltar to begin their invasion of the Iberian Peninsula (Al-Andalus). |
| 48333 | April 27 | Event | 1296 – First War of Scottish Independence: John Balliol's Scottish army is defeated by an English army commanded by John de Warenne, 6th Earl of Surrey at the Battle of Dunbar. |
| 48334 | April 27 | Event | 1509 – Pope Julius II places the Italian state of Venice under interdict. |
| 48335 | April 27 | Event | 1521 – Battle of Mactan: Explorer Ferdinand Magellan is killed by natives in the Philippines led by chief Lapu-Lapu. |
| 48336 | April 27 | Event | 1522 – Combined forces of Spain and the Papal States defeat a French and Venetian army at the Battle of Bicocca. |
| 48337 | April 27 | Event | 1539 – Re-founding of the city of Bogotá, New Granada (now Colombia), by Nikolaus Federmann and Sebastián de Belalcázar. |
| 48338 | April 27 | Event | 1565 – Cebu is established becoming the first Spanish settlement in the Philippines. |
| 48339 | April 27 | Event | 1578 – Duel of the Mignons claims the lives of two favourites of Henry III of France and two favorites of Henry I, Duke of Guise. |
| 48340 | April 27 | Event | 1595 – The relics of Saint Sava are incinerated in Belgrade by the Ottomans, where today the largest Orthodox church building in the world stands |
| 48341 | April 27 | Event | 1650 – The Battle of Carbisdale: A Royalist army from Orkney invades mainland Scotland but is defeated by a Covenanter army. |
| 48342 | April 27 | Event | 1667 – The blind and impoverished John Milton sells the copyright of Paradise Lost for £10. |
| 48343 | April 27 | Event | 1749 – First performance of George Frideric Handel's Music for the Royal Fireworks in Green Park, London. |
| 48344 | April 27 | Event | 1777 – American Revolutionary War: The Battle of Ridgefield: A British invasion force engages and defeats Continental Army regulars and militia irregulars at Ridgefield, Connecticut. |
| 48345 | April 27 | Event | 1805 – First Barbary War: United States Marines and Berbers attack the Tripolitan city of Derna (The "shores of Tripoli" part of the Marines' Hymn). |
| 48346 | April 27 | Event | 1810 – Beethoven composes Für Elise. |
| 48347 | April 27 | Event | 1813 – War of 1812: American troops capture the capital of Upper Canada in the Battle of York (present day Toronto, Canada). |
| 48348 | April 27 | Event | 1840 – Foundation stone for new Palace of Westminster, London, is laid by wife of Sir Charles Barry. |
| 48349 | April 27 | Event | 1861 – American President Abraham Lincoln suspends the writ of habeas corpus. |
| 48350 | April 27 | Event | 1865 – The New York State Senate creates Cornell University as the state's land grant institution. |
| 48351 | April 27 | Event | 1865 – The steamboat Sultana, carrying 2,400 passengers, explodes and sinks in the Mississippi River, killing 1,800, most of whom are Union survivors of the Andersonville and Cahaba Prisons. |
| 48352 | April 27 | Event | 1904 – The Australian Labor Party becomes the first such party to gain national government, under Chris Watson. |
| 48353 | April 27 | Event | 1909 – Sultan of Ottoman Empire Abdul Hamid II is overthrown, and is succeeded by his brother, Mehmed V. |
| 48354 | April 27 | Event | 1911 – Following the resignation and death of William P. Frye, a compromise is reached to rotate the office of President pro tempore of the United States Senate. |
| 48355 | April 27 | Event | 1914 – Honduras becomes a signatory to the Buenos Aires copyright treaty. |
| 48356 | April 27 | Event | 1927 – Carabineros de Chile (Chilean national police force and gendarmerie) are created. |
| 48357 | April 27 | Event | 1936 – The United Auto Workers (UAW) gains autonomy from the American Federation of Labor. |
| 48358 | April 27 | Event | 1941 – World War II: German troops enter Athens. |
| 48359 | April 27 | Event | 1941 – World War II: The Communist Party of Slovenia, the Slovene Christian Socialists, the left-wing Slovene Sokols (also known as "National Democrats") and a group of progressive intellectuals establish the Liberation Front of the Slovene Nation. |
| 48360 | April 27 | Event | 1945 – World War II: German troops are finally expelled from Finnish Lapland. |