| 48361 | April 27 | Event | 1945 – World War II: Benito Mussolini is arrested by Italian partisans in Dongo, while attempting escape disguised as a German soldier. |
| 48362 | April 27 | Event | 1950 – Apartheid: In South Africa, the Group Areas Act is passed formally segregating races. |
| 48363 | April 27 | Event | 1953 – Operation Moolah offers $50,000 to any pilot who defected with a fully mission-capable Mikoyan-Gurevich MiG-15 to South Korea. The first pilot was to receive $100,000. |
| 48364 | April 27 | Event | 1960 – Togo gains independence from French-administered UN trusteeship. |
| 48365 | April 27 | Event | 1961 – Sierra Leone is granted its independence from the United Kingdom, with Milton Margai as the first Prime Minister. |
| 48366 | April 27 | Event | 1967 – Expo 67 officially opens in Montreal, Canada with a large opening ceremony broadcast around the world. It opens to the public the next day. |
| 48367 | April 27 | Event | 1974 – Ten thousand march in Washington, D.C., calling for the impeachment of U.S. President Richard Nixon |
| 48368 | April 27 | Event | 1977 – Twenty-eight people are killed in the Guatemala City air disaster. |
| 48369 | April 27 | Event | 1978 – Former United States President Nixon aide John D. Ehrlichman is released from an Arizona prison after serving 18 months for Watergate-related crimes. |
| 48370 | April 27 | Event | 1981 – Xerox PARC introduces the computer mouse. |
| 48371 | April 27 | Event | 1986 – The city of Pripyat as well as the surrounding areas are evacuated due to Chernobyl disaster. |
| 48372 | April 27 | Event | 1987 – The U.S. Department of Justice bars Austrian President Kurt Waldheim from entering the United States, saying he had aided in the deportation and execution of thousands of Jews and others as a German Army officer during World War II. |
| 48373 | April 27 | Event | 1989 – The April 27 demonstrations, student-led protests responding to the April 26 Editorial, during the Tiananmen Square protests of 1989. |
| 48374 | April 27 | Event | 1992 – The Federal Republic of Yugoslavia, comprising Serbia and Montenegro, is proclaimed. |
| 48375 | April 27 | Event | 1992 – Betty Boothroyd becomes the first woman to be elected Speaker of the British House of Commons in its 700-year history. |
| 48376 | April 27 | Event | 1992 – The Russian Federation and 12 other former Soviet republics become members of the International Monetary Fund and the World Bank. |
| 48377 | April 27 | Event | 1993 – All members of the Zambia national football team lose their lives in a plane crash off Libreville, Gabon en route to Dakar, Senegal to play a 1994 FIFA World Cup qualifying match against Senegal. |
| 48378 | April 27 | Event | 1994 – South African general election: The first democratic general election in South Africa, in which black citizens could vote. The Interim Constitution comes into force. |
| 48379 | April 27 | Event | 1996 – The 1996 Lebanon war ends. |
| 48380 | April 27 | Event | 2002 – The last successful telemetry from the NASA space probe Pioneer 10. |
| 48381 | April 27 | Event | 2005 – The superjumbo jet aircraft Airbus A380 makes its first flight from Toulouse, France. An accident involving a bus and a train occurs in Polgahawela, Sri Lanka. |
| 48382 | April 27 | Event | 2006 – Construction begins on the Freedom Tower (later renamed One World Trade Center) in New York City. |
| 48383 | April 27 | Event | 2007 – Estonian authorities remove the Bronze Soldier, a Soviet Red Army war memorial in Tallinn, amid political controversy with Russia. |
| 48384 | April 27 | Event | 2011 – The April 25–28 tornado outbreak devastates parts of the Southeastern United States, especially the states of Alabama, Mississippi, Georgia, and Tennessee. Two hundred five tornadoes touched down on April 27 alone, killing more than 300 and injurin |
| 48385 | April 27 | Event | 2012 – At least four explosions hit the Ukrainian city of Dnipropetrovsk with at least 27 people injured. |
| 48386 | April 27 | Event | 2014 – Popes John XXIII and John Paul II are declared saints in the first papal canonization since 1954. |
| 48387 | April 27 | Event | 2014 – A tornado outbreak over much of the eastern United States kills 35 people. |
| 48388 | April 27 | Birth | 1650 – Charlotte Amalie of Hesse-Kassel (d. 1714) |
| 48389 | April 27 | Birth | 1701 – Charles Emmanuel III of Sardinia (d. 1773) |
| 48390 | April 27 | Birth | 1718 – Thomas Lewis, Irish-American surveyor and lawyer (d. 1790) |