| 48451 | April 27 | Birth | 1922 – Jack Klugman, American actor, director, and screenwriter (d. 2012) |
| 48452 | April 27 | Birth | 1922 – Sheila Scott, English nurse and pilot (d. 1988) |
| 48453 | April 27 | Birth | 1924 – Vernon B. Romney, American lawyer and politician, 14th Attorney General of Utah (d. 2013) |
| 48454 | April 27 | Birth | 1925 – Derek Chinnery, English broadcaster (d. 2015) |
| 48455 | April 27 | Birth | 1926 – Tim LaHaye, American minister and author |
| 48456 | April 27 | Birth | 1926 – Basil A. Paterson, American lawyer and politician, 59th Secretary of State of New York (d. 2014) |
| 48457 | April 27 | Birth | 1926 – Alan Reynolds, English painter and educator (d. 2014) |
| 48458 | April 27 | Birth | 1927 – Tato Bores, Argentinian actor (d. 1996) |
| 48459 | April 27 | Birth | 1927 – Charlie Fonville, American shot putter and lawyer (d. 1994) |
| 48460 | April 27 | Birth | 1927 – Connie Kay, American drummer (Modern Jazz Quartet) (d. 1994) |
| 48461 | April 27 | Birth | 1927 – Coretta Scott King, American activist and author (d. 2006) |
| 48462 | April 27 | Birth | 1927 – Joe Moakley, American soldier, lawyer, and politician (d. 2001) |
| 48463 | April 27 | Birth | 1929 – Nina Ponomaryova, Russian discus thrower and coach |
| 48464 | April 27 | Birth | 1931 – Igor Oistrakh, Ukrainian violinist and educator |
| 48465 | April 27 | Birth | 1932 – Anouk Aimée, French actress |
| 48466 | April 27 | Birth | 1932 – Pik Botha, South African lawyer, politician, and diplomat, 8th South African Ambassador to the United States |
| 48467 | April 27 | Birth | 1932 – Maxine Brown, American singer-songwriter (The Browns) |
| 48468 | April 27 | Birth | 1932 – Casey Kasem, American radio host, producer, and actor, co-created American Top 40 (d. 2014) |
| 48469 | April 27 | Birth | 1932 – Derek Minter, English motorcycle racer (d. 2015) |
| 48470 | April 27 | Birth | 1932 – Gian-Carlo Rota, Italian-American mathematician and philosopher (d. 1999) |
| 48471 | April 27 | Birth | 1933 – Peter Imbert, Baron Imbert, English police officer and politician, Lord Lieutenant for Greater London |
| 48472 | April 27 | Birth | 1934 – Brennan Manning, American priest and author (d. 2013) |
| 48473 | April 27 | Birth | 1934 – Jean Valentine, American poet and academic |
| 48474 | April 27 | Birth | 1935 – Theodoros Angelopoulos, Greek director, producer, and screenwriter (d. 2012) |
| 48475 | April 27 | Birth | 1935 – Ron Morris, American pole vaulter and coach |
| 48476 | April 27 | Birth | 1936 – Geoffrey Shovelton, English singer and illustrator |
| 48477 | April 27 | Birth | 1937 – Sandy Dennis, American actress (d. 1992) |
| 48478 | April 27 | Birth | 1937 – Robin Eames, Irish archbishop |
| 48479 | April 27 | Birth | 1937 – Richard Perham, English biologist and academic (d. 2015) |
| 48480 | April 27 | Birth | 1938 – Earl Anthony, American bowler and sportscaster (d. 2001) |