| 1 | 1789-1797 | George Washington | Martha Washington | John Adams |
| 2 | 1797-1801 | John Adams | Abigail Adams | Thomas Jefferson |
| 3 | 1801-1805 | Thomas Jefferson | Martha Wayles Skelton Jefferson | Aaron Burr |
| 4 | 1805-1809 | Thomas Jefferson | Martha Wayles Skelton Jefferson | George Clinton |
| 5 | 1809-1812 | James Madison | Dolley Madison | George Clinton |
| 6 | 1812-1813 | James Madison | Dolley Madison | office vacant |
| 7 | 1813-1814 | James Madison | Dolley Madison | Elbridge Gerry |
| 8 | 1814-1817 | James Madison | Dolley Madison | office vacant |
| 9 | 1817-1825 | James Monroe | Elizabeth Kortright Monroe | Daniel D. Tompkins |
| 10 | 1825-1829 | John Quincy Adams | Louisa Catherine Adams | John C. Calhoun |
| 11 | 1829-1832 | Andrew Jackson | Rachel Jackson | John C. Calhoun |
| 12 | 1833-1837 | Andrew Jackson | Rachel Jackson | Martin Van Buren |
| 13 | 1837-1841 | Martin Van Buren | Hannah Hoes Van Buren | Richard M. Johnson |
| 14 | 1841 | William Henry Harrison | Anna Tuthill Symmes Harrison | John Tyler |
| 15 | 1841-1845 | John Tyler | Letitia Christian Tyler and Julia Gardiner Tyler | office vacant |
| 16 | 1845-1849 | James K. Polk | Sarah Childress Polk | George M. Dallas |
| 17 | 1849-1850 | Zachary Taylor | Margaret Mackall Smith Taylor | Millard Fillmore |
| 18 | 1850-1853 | Millard Fillmore | Abigail Powers Fillmore | office vacant |
| 19 | 1853 | Franklin Pierce | Jane M. Pierce | William R. King |
| 20 | 1853-1857 | Franklin Pierce | Jane M. Pierce | office vacant |
| 21 | 1857-1861 | James Buchanan | (never married) | John C. Breckinridge |