| 43741 | April 16 | Event | 1894 – Manchester City F.C. was formed from Ardwick A.F.C.. |
| 43742 | April 16 | Event | 1908 – Natural Bridges National Monument is established in Utah. |
| 43743 | April 16 | Event | 1910 – The oldest existing indoor ice hockey arena still used for the sport in the 21st century, Boston Arena, opens for the first time. |
| 43744 | April 16 | Event | 1912 – Harriet Quimby becomes the first woman to fly an airplane across the English Channel. |
| 43745 | April 16 | Event | 1917 – Vladimir Lenin returns to Petrograd, Russia from exile in Switzerland. |
| 43746 | April 16 | Event | 1919 – Mohandas Gandhi organizes a day of "prayer and fasting" in response to the killing of Indian protesters in the Jallianwala Bagh massacre by the British colonial troops three days earlier. |
| 43747 | April 16 | Event | 1919 – Polish–Soviet War: The Polish army launches the Vilna offensive to capture Vilnius in modern Lithuania. |
| 43748 | April 16 | Event | 1922 – The Treaty of Rapallo, pursuant to which Germany and the Soviet Union re-establish diplomatic relations, is signed. |
| 43749 | April 16 | Event | 1925 – During the Communist St Nedelya Church assault in Sofia, Bulgaria, 150 are killed and 500 are wounded. |
| 43750 | April 16 | Event | 1940 – Bob Feller of the Cleveland Indians throws the only Opening Day no-hitter in the history of Major League Baseball, beating the Chicago White Sox 1–0. |
| 43751 | April 16 | Event | 1941 – World War II: The Italian convoy Duisburg, directed to Tunisia, is attacked and destroyed by British ships. |
| 43752 | April 16 | Event | 1941 – World War II: The Ustaše, a Croatian ultranationalist organization is put in charge of the Independent State of Croatia by the Axis powers after the Axis Operation 25 invasion. |
| 43753 | April 16 | Event | 1944 – World War II: Allied forces start bombing Belgrade, killing about 1,100 people. This bombing fell on the Orthodox Christian Easter. |
| 43754 | April 16 | Event | 1945 – World War II: The Red Army begins the final assault on German forces around Berlin, with nearly one million troops fighting in the Battle of the Seelow Heights. |
| 43755 | April 16 | Event | 1945 – The United States Army liberates Nazi Sonderlager (high security) prisoner-of-war camp Oflag IV-C (better known as Colditz). |
| 43756 | April 16 | Event | 1945 – More than 7,000 die when the German refugee ship Goya is sunk by a Soviet submarine. |
| 43757 | April 16 | Event | 1947 – Texas City disaster: An explosion on board a freighter in port causes the city of Texas City, Texas, to catch fire, killing almost 600. |
| 43758 | April 16 | Event | 1947 – Bernard Baruch coins the term "Cold War" to describe the relationship between the United States and the Soviet Union. |
| 43759 | April 16 | Event | 1953 – Queen Elizabeth II launches the Royal Yacht HMY Britannia. |
| 43760 | April 16 | Event | 1961 – In a nationally broadcast speech, Cuban leader Fidel Castro declares that he is a Marxist–Leninist and that Cuba is going to adopt Communism. |
| 43761 | April 16 | Event | 1962 – Walter Cronkite takes over as the lead news anchor of the CBS Evening News, during which time he would become "the most trusted man in America". |
| 43762 | April 16 | Event | 1963 – Dr. Martin Luther King Jr. pens his Letter from Birmingham Jail while incarcerated in Birmingham, Alabama for protesting against segregation. |
| 43763 | April 16 | Event | 1972 – Apollo program: The launch of Apollo 16 from Cape Canaveral, Florida. |
| 43764 | April 16 | Event | 1990 – The "Doctor of Death", Jack Kevorkian, participates in his first assisted suicide. |
| 43765 | April 16 | Event | 1992 – The Katina P runs aground off of Maputo, Mozambique and 60,000 tons of crude oil spill into the ocean. |
| 43766 | April 16 | Event | 1995 – George W. Bush names April 16 as Selena Day in Texas, after she was killed two weeks earlier. |
| 43767 | April 16 | Event | 2001 – India and Bangladesh begin a five-day border conflict, but are unable to resolve the disputes about their border. |
| 43768 | April 16 | Event | 2003 – The Treaty of Accession is signed in Athens admitting ten new member states to the European Union. |
| 43769 | April 16 | Event | 2007 – Virginia Tech shooting: Seung-Hui Cho guns down 32 people and injures 17 before committing suicide. |
| 43770 | April 16 | Event | 2012 – The trial for Anders Behring Breivik, the perpetrator of the 2011 Norway attacks, begins in Oslo, Norway. |