| 46201 | April 21 | Death | 1073 – Pope Alexander II |
| 46202 | April 21 | Death | 1109 – Anselm of Canterbury, Italian-English archbishop and saint (b. 1033) |
| 46203 | April 21 | Death | 1136 – Stephen, Count of Tréguier Breton noblemen (b. c. 1058/62) |
| 46204 | April 21 | Death | 1142 – Peter Abelard, French philosopher and theologian (b. 1079) |
| 46205 | April 21 | Death | 1509 – Henry VII of England (b. 1457) |
| 46206 | April 21 | Death | 1557 – Petrus Apianus, German mathematician and astronomer (b. 1495) |
| 46207 | April 21 | Death | 1574 – Cosimo I de' Medici, Grand Duke of Tuscany (b. 1519) |
| 46208 | April 21 | Death | 1605 – Nyzette Cheveron, Belgian woman accused of witchcraft |
| 46209 | April 21 | Death | 1699 – Jean Racine, French playwright and poet (b. 1639) |
| 46210 | April 21 | Death | 1701 – Asano Naganori, Japanese daimyo (b. 1667) |
| 46211 | April 21 | Death | 1719 – Philippe de La Hire, French mathematician and astronomer (b. 1640) |
| 46212 | April 21 | Death | 1720 – Antoine Hamilton, Irish-French soldier and author (b. 1646) |
| 46213 | April 21 | Death | 1722 – Robert Beverley, Jr., English-American historian and author (b. 1673) |
| 46214 | April 21 | Death | 1736 – Prince Eugene of Savoy (b. 1663) |
| 46215 | April 21 | Death | 1740 – Thomas Tickell, English poet and author (b. 1685) |
| 46216 | April 21 | Death | 1792 – Tiradentes, Brazilian activist (b. 1746) |
| 46217 | April 21 | Death | 1815 – Joseph Winston, American soldier and politician (b. 1746) |
| 46218 | April 21 | Death | 1825 – Johann Friedrich Pfaff, German mathematician and academic (b. 1765) |
| 46219 | April 21 | Death | 1852 – Ivan Nabokov, Russian general (b. 1787) |
| 46220 | April 21 | Death | 1863 – Sir Robert Bateson, 1st Baronet, Irish politician (b. 1782) |
| 46221 | April 21 | Death | 1868 – Henry James O'Farrell, Australian attempted assassin of Alfred, Duke of Saxe-Coburg and Gotha (b. 1833) |
| 46222 | April 21 | Death | 1900 – Vikramatji Khimojiraj, Indian ruler (b. 1819) |
| 46223 | April 21 | Death | 1910 – Mark Twain, American author and educator (b. 1835) |
| 46224 | April 21 | Death | 1918 – Antonio Pini-Corsi, Italian actor and singer (b. 1858) |
| 46225 | April 21 | Death | 1918 – Manfred von Richthofen, German captain and pilot (b. 1892) |
| 46226 | April 21 | Death | 1922 – Alessandro Moreschi, Italian singer (b. 1858) |
| 46227 | April 21 | Death | 1924 – Eleonora Duse, Italian actress (b. 1858) |
| 46228 | April 21 | Death | 1930 – Robert Bridges, English poet and author (b. 1844) |
| 46229 | April 21 | Death | 1932 – Friedrich Gustav Piffl, Bohemian cardinal (b. 1864) |
| 46230 | April 21 | Death | 1938 – Muhammad Iqbal, Indian-Pakistani philosopher and poet (b. 1877) |