| 46291 | April 21 | Death | 2013 – Captain Steve, American race horse (b. 1997) |
| 46292 | April 21 | Death | 2014 – Herb Gray, Canadian lawyer and politician, 7th Deputy Prime Minister of Canada (b. 1931) |
| 46293 | April 21 | Death | 2014 – Janet Gray Hayes, American politician, 60th Mayor of San Jose (b. 1926) |
| 46294 | April 21 | Death | 2014 – George H. Heilmeier, American engineer (b. 1936) |
| 46295 | April 21 | Death | 2014 – Alexander Lenkov, Russian actor (b. 1943) |
| 46296 | April 21 | Death | 2014 – Win Tin, Burmese journalist and politician, co-founded the National League for Democracy (b. 1930) |
| 46297 | April 21 | Death | 2015 – M. H. Abrams, American author, critic, and academic (b. 1912) |
| 46298 | April 21 | Death | 2015 – Steve Byrnes, American sportscaster and producer (b. 1959) |
| 46299 | April 21 | Death | 2015 – John Moshoeu, South African footballer and manager (b. 1965) |
| 46300 | April 21 | Death | 2015 – Janaki Ballabh Patnaik, Indian politician, Governor of Assam (b. 1927) |
| 46301 | April 21 | Death | 2015 – Sydney Valpy Radley-Walters, Canadian general (b. 1920) |
| 46302 | April 21 | Death | 2015 – Betsy von Furstenberg, German-American actress (b. 1931) |
| 46303 | April 21 | Holiday and observance | Aggie Muster (Texas A&M University) |
| 46304 | April 21 | Holiday and observance | Birthday of Rome (Rome) |
| 46305 | April 21 | Holiday and observance | Christian feast day:AbdecalasAnastasius SinaitaAnselm of CanterburyBeunoConrad of ParzhamHoly Infant of Good HealthShemon Bar SabbaeWolbodoApril 21 (Eastern Orthodox liturgics) |
| 46306 | April 21 | Holiday and observance | Civil Service Day (India) |
| 46307 | April 21 | Holiday and observance | Grounation Day (Rastafari movement) |
| 46308 | April 21 | Holiday and observance | Heroic Defense of Veracruz (Mexico) |
| 46309 | April 21 | Holiday and observance | Inauguration of Brasília (Distrito Federal, Brazil) |
| 46310 | April 21 | Holiday and observance | Kang Pan-sok’s Birthday (North Korea) |
| 46311 | April 21 | Holiday and observance | Kartini Day (Indonesia) |
| 46312 | April 21 | Holiday and observance | National Tree Planting Day (Kenya) |
| 46313 | April 21 | Holiday and observance | San Jacinto Day (Texas) |
| 46314 | April 21 | Holiday and observance | The first day of the festival of Ridván. (Bahá'í Faith) |
| 46315 | April 21 | Holiday and observance | Tiradentes (Brazil) |
| 46316 | April 21 | Holiday and observance | Vietnam Book Day (Vietnam) |
| 46317 | April 22 | Event | 238 – Year of the Six Emperors: The Roman Senate outlaws emperor Maximinus Thrax for his bloodthirsty proscriptions in Rome and nominates two of its members, Pupienus and Balbinus, to the throne. |
| 46318 | April 22 | Event | 1500 – Portuguese navigator Pedro Álvares Cabral lands in Brazil. |
| 46319 | April 22 | Event | 1519 – Spanish conquistador Hernán Cortés establishes a settlement at Veracruz, Mexico. |
| 46320 | April 22 | Event | 1529 – Treaty of Zaragoza divides the eastern hemisphere between Spain and Portugal along a line 297.5 leagues or 17° east of the Moluccas. |