| 46321 | April 22 | Event | 1622 – The Capture of Ormuz by the East India Company ends Portuguese control of Hormuz Island. |
| 46322 | April 22 | Event | 1809 – The second day of the Battle of Eckmühl: The Austrian army is defeated by the First French Empire army led by Napoleon and driven over the Danube in Regensburg. |
| 46323 | April 22 | Event | 1836 – Texas Revolution: A day after the Battle of San Jacinto, forces under Texas General Sam Houston identify Mexican General Antonio López de Santa Anna among the captives of the battle when one of his fellow captives mistakenly gives away his identity |
| 46324 | April 22 | Event | 1864 – The U.S. Congress passes the Coinage Act of 1864 that mandates that the inscription In God We Trust be placed on all coins minted as United States currency. |
| 46325 | April 22 | Event | 1876 – The first game in the history of the National League was played at the Jefferson Street Grounds in Philadelphia. This game is often pointed to as the beginning of the MLB. |
| 46326 | April 22 | Event | 1889 – At noon, thousands rush to claim land in the Land Rush of 1889. Within hours the cities of Oklahoma City and Guthrie are formed with populations of at least 10,000. |
| 46327 | April 22 | Event | 1898 – Spanish–American War: The USS Nashville captures a Spanish merchant ship. |
| 46328 | April 22 | Event | 1906 – The 1906 Summer Olympics, not now recognized as part of the official Olympic Games, open in Athens. |
| 46329 | April 22 | Event | 1911 – Tsinghua University, one of mainland China's leading universities, is founded. |
| 46330 | April 22 | Event | 1912 – Pravda, the "voice" of the Communist Party of the Soviet Union, begins publication in Saint Petersburg. |
| 46331 | April 22 | Event | 1915 – The use of poison gas in World War I escalates when chlorine gas is released as a chemical weapon in the Second Battle of Ypres. |
| 46332 | April 22 | Event | 1930 – The United Kingdom, Japan and the United States sign the London Naval Treaty regulating submarine warfare and limiting shipbuilding. |
| 46333 | April 22 | Event | 1944 – The 1st Air Commando Group using Sikorsky R-4 helicopters stage the first use of helicopters in combat with combat search and rescue operations in the China Burma India Theater. |
| 46334 | April 22 | Event | 1944 – World War II: Operation Persecution is initiated: Allied forces land in the Hollandia (currently known as Jayapura) area of New Guinea. |
| 46335 | April 22 | Event | 1945 – World War II: Prisoners at the Jasenovac concentration camp revolt. Five hundred twenty are killed and 80 escape. |
| 46336 | April 22 | Event | 1945 – World War II: Führerbunker: After learning that Soviet forces have taken Eberswalde without a fight, Adolf Hitler admits defeat in his underground bunker and states that suicide is his only recourse. |
| 46337 | April 22 | Event | 1948 – Arab–Israeli War: Haifa, a major port of Israel, is captured from Arab forces. |
| 46338 | April 22 | Event | 1951 – Korean War: The Chinese People's Volunteer Army begin assaulting positions defended by the Royal Australian Regiment and the Princess Patricia's Canadian Light Infantry at the Battle of Kapyong. |
| 46339 | April 22 | Event | 1954 – Red Scare: Witnesses begin testifying and live television coverage of the Army–McCarthy hearings begins. |
| 46340 | April 22 | Event | 1964 – The 1964-1965 New York World's Fair opens for its first season. |
| 46341 | April 22 | Event | 1969 – British yachtsman Sir Robin Knox-Johnston wins the Sunday Times Golden Globe Race and completes the first solo non-stop circumnavigation of the world. |
| 46342 | April 22 | Event | 1970 – The first Earth Day is celebrated. |
| 46343 | April 22 | Event | 1972 – Vietnam War: Increased American bombing in Vietnam prompts anti-war protests in Los Angeles, New York City, and San Francisco. |
| 46344 | April 22 | Event | 1977 – Optical fiber is first used to carry live telephone traffic. |
| 46345 | April 22 | Event | 1983 – The German magazine Stern claims that the "Hitler Diaries" had been found in wreckage in East Germany the diaries are subsequently revealed to be forgeries. |
| 46346 | April 22 | Event | 1992 – In a series of explosions in Guadalajara, Mexico, 206 people are killed, nearly 500 injured and 15,000 left homeless. |
| 46347 | April 22 | Event | 1993 – Version 1.0 of the Mosaic web browser is released. |
| 46348 | April 22 | Event | 1997 – Haouch Khemisti massacre in Algeria where 93 villagers are killed. |
| 46349 | April 22 | Event | 1997 – The Japanese embassy hostage crisis ends in Lima, Peru. |
| 46350 | April 22 | Event | 1998 – Disney's Animal Kingdom opens at Walt Disney World near Orlando, Florida, United States. |