| 46351 | April 22 | Event | 2000 – In a pre-dawn raid, federal agents seize six-year-old Elián González from his relatives' home in Miami. |
| 46352 | April 22 | Event | 2000 – The Big Number Change takes place in the United Kingdom. |
| 46353 | April 22 | Event | 2004 – Two fuel trains collide in Ryongchon, North Korea, killing up to 150 people. |
| 46354 | April 22 | Event | 2005 – Japan's Prime Minister Junichiro Koizumi apologizes for Japan's war record. |
| 46355 | April 22 | Event | 2008 – The United States Air Force retires the remaining F-117 Nighthawk aircraft in service. |
| 46356 | April 22 | Event | 2013 – Six people die in a shooting in Belgorod, Russia. |
| 46357 | April 22 | Event | 2013 – The Royal Canadian Mounted Police arrest and charge two men with plotting to disrupt a Toronto area train service in a plot claimed to be backed by Al-Qaeda elements. |
| 46358 | April 22 | Event | 2014 – More than 60 people are killed and 80 are seriously injured in a train crash in the Democratic Republic of the Congo's Katanga Province. |
| 46359 | April 22 | Birth | 1451 – Isabella I of Castile (d. 1504) |
| 46360 | April 22 | Birth | 1518 – Antoine of Navarre (d. 1562) |
| 46361 | April 22 | Birth | 1592 – Wilhelm Schickard, German astronomer and mathematician (d. 1635) |
| 46362 | April 22 | Birth | 1610 – Pope Alexander VIII (d. 1691) |
| 46363 | April 22 | Birth | 1658 – Giuseppe Torelli, Italian violinist and composer (d. 1709) |
| 46364 | April 22 | Birth | 1690 – John Carteret, 2nd Earl Granville, English politician, Lord President of the Council (d. 1763) |
| 46365 | April 22 | Birth | 1707 – Henry Fielding, English novelist and playwright (d. 1754) |
| 46366 | April 22 | Birth | 1711 – Paul II Anton, Prince Esterházy, Austrian soldier (d. 1762) |
| 46367 | April 22 | Birth | 1724 – Immanuel Kant, German anthropologist, philosopher, and academic (d. 1804) |
| 46368 | April 22 | Birth | 1732 – John Johnson, English architect and surveyor (d. 1814) |
| 46369 | April 22 | Birth | 1744 – James Sullivan, American lawyer and politician, 7th Governor of Massachusetts (d. 1808) |
| 46370 | April 22 | Birth | 1757 – Alessandro Rolla, Italian violinist and composer (d. 1841) |
| 46371 | April 22 | Birth | 1766 – Germaine de Staël, French philosopher and author (d. 1817) |
| 46372 | April 22 | Birth | 1812 – Solomon Caesar Malan, Swiss-English orientalist (d. 1894) |
| 46373 | April 22 | Birth | 1816 – Charles-Denis Bourbaki, French general (d. 1897) |
| 46374 | April 22 | Birth | 1832 – Julius Sterling Morton, American journalist and politician, 3rd United States Secretary of Agriculture (d. 1902) |
| 46375 | April 22 | Birth | 1844 – Lewis Powell, American soldier, attempted assassin of William H. Seward (d. 1865) |
| 46376 | April 22 | Birth | 1852 – William IV, Grand Duke of Luxembourg (d. 1912) |
| 46377 | April 22 | Birth | 1854 – Henri La Fontaine, Belgian lawyer and author, Nobel Prize laureate (d. 1943) |
| 46378 | April 22 | Birth | 1860 – Ada Rehan, Irish-American actress (d. 1916) |
| 46379 | April 22 | Birth | 1868 – Archduchess Marie Valerie of Austria (d. 1924) |
| 46380 | April 22 | Birth | 1870 – Vladimir Lenin, Russian lawyer and politician (d. 1924) |