| 46471 | April 22 | Birth | 1946 – Paul Davies, English physicist and author |
| 46472 | April 22 | Birth | 1946 – Nicole Garcia, French actress and director |
| 46473 | April 22 | Birth | 1946 – Louise Harel, Canadian lawyer and politician |
| 46474 | April 22 | Birth | 1946 – Archy Kirkwood, Baron Kirkwood of Kirkhope, Scottish lawyer and politician |
| 46475 | April 22 | Birth | 1946 – Nicholas Stern, Baron Stern of Brentford, English economist and academic |
| 46476 | April 22 | Birth | 1946 – John Waters, American actor, director, producer, and screenwriter |
| 46477 | April 22 | Birth | 1948 – Larry Groce, American singer-songwriter and radio host |
| 46478 | April 22 | Birth | 1948 – John Pritchard, English bishop |
| 46479 | April 22 | Birth | 1950 – Peter Frampton, English singer-songwriter, guitarist, and producer (The Herd and Humble Pie) |
| 46480 | April 22 | Birth | 1950 – Jancis Robinson, English journalist and critic |
| 46481 | April 22 | Birth | 1950 – Zygi Wilf, German-American businessman |
| 46482 | April 22 | Birth | 1951 – Paul Carrack, English singer-songwriter and guitarist (Ace, Squeeze, Mike + The Mechanics, and Roxy Music) |
| 46483 | April 22 | Birth | 1951 – Aivars Kalējs, Latvian organist, composer, and pianist |
| 46484 | April 22 | Birth | 1951 – Ana María Shua, Argentinian author and poet |
| 46485 | April 22 | Birth | 1952 – François Berléand, French actor |
| 46486 | April 22 | Birth | 1952 – Marilyn Chambers, American porn actress and screenwriter (d. 2009) |
| 46487 | April 22 | Birth | 1952 – Phil Smith, American basketball player (d. 2002) |
| 46488 | April 22 | Birth | 1953 – Valeri Bondarenko, Estonian footballer and coach |
| 46489 | April 22 | Birth | 1953 – Richard Broadbent, English businessman |
| 46490 | April 22 | Birth | 1953 – Tom Griswold, American radio host |
| 46491 | April 22 | Birth | 1953 – Juhani Komulainen, Finnish composer |
| 46492 | April 22 | Birth | 1954 – Jōji Nakata, Japanese voice actor |
| 46493 | April 22 | Birth | 1955 – David Collier, English businessman |
| 46494 | April 22 | Birth | 1955 – Johnnie To, Hong Kong director and producer |
| 46495 | April 22 | Birth | 1957 – Donald Tusk, Polish journalist and politician, 14th Prime Minister of Poland |
| 46496 | April 22 | Birth | 1958 – Ken Olandt, American actor and producer |
| 46497 | April 22 | Birth | 1959 – Keith Boanas, English footballer and manager |
| 46498 | April 22 | Birth | 1959 – Tim Bowman, American singer-songwriter and guitarist |
| 46499 | April 22 | Birth | 1959 – Terry Francona, American baseball player, coach, and manager |
| 46500 | April 22 | Birth | 1959 – Catherine Mary Stewart, Canadian actress |