| 46681 | April 22 | Death | 1999 – Munir Ahmad Khan, Pakistani-Austrian physicist and engineer (b. 1926) |
| 46682 | April 22 | Death | 1999 – Apostolos Nikolaidis, Greek-American singer (b. 1938) |
| 46683 | April 22 | Death | 2002 – Linda Lovelace, American porn actress (b. 1949) |
| 46684 | April 22 | Death | 2003 – Felice Bryant, American songwriter (b. 1925) |
| 46685 | April 22 | Death | 2003 – James H. Critchfield, American CIA officer (b. 1917) |
| 46686 | April 22 | Death | 2003 – Martha Griffiths, American lawyer, judge, and politician, 58th Lieutenant Governor of Michigan (b. 1912) |
| 46687 | April 22 | Death | 2003 – Mike Larrabee, American runner (b. 1933) |
| 46688 | April 22 | Death | 2004 – Michael Christie, American golfer (b.1969) |
| 46689 | April 22 | Death | 2004 – Jason Dunham, American soldier, Medal of Honor recipient (b. 1981) |
| 46690 | April 22 | Death | 2004 – Pat Tillman, American football player and soldier (b. 1976) |
| 46691 | April 22 | Death | 2005 – Norman Bird, English actor (b. 1920) |
| 46692 | April 22 | Death | 2005 – Erika Fuchs, German translator (b. 1906) |
| 46693 | April 22 | Death | 2005 – Philip Morrison, American physicist and academic (b. 1915) |
| 46694 | April 22 | Death | 2006 – Henriette Avram, American computer scientist and academic (b. 1919) |
| 46695 | April 22 | Death | 2006 – D'Iberville Fortier, Canadian diplomat (b. 1926) |
| 46696 | April 22 | Death | 2006 – Alida Valli, Italian actress and singer (b. 1921) |
| 46697 | April 22 | Death | 2007 – Juanita Millender-McDonald, American educator and politician (b. 1938) |
| 46698 | April 22 | Death | 2008 – Cameron Argetsinger, American race car driver and lawyer (b. 1921) |
| 46699 | April 22 | Death | 2008 – Ed Chynoweth, Canadian businessman (b. 1941) |
| 46700 | April 22 | Death | 2008 – Paul Davis, American singer-songwriter (b. 1948) |
| 46701 | April 22 | Death | 2010 – Richard Barrett, American lawyer and activist (b. 1943) |
| 46702 | April 22 | Death | 2011 – Moin Akhter, Pakistani actor (b. 1950) |
| 46703 | April 22 | Death | 2012 – John Amabile, American football player and coach (b. 1939) |
| 46704 | April 22 | Death | 2012 – Bill Granger, American author (b. 1941) |
| 46705 | April 22 | Death | 2012 – Buzz Potamkin, American director and producer (b. 1945) |
| 46706 | April 22 | Death | 2012 – George Rathmann, American chemist, biologist, and businessman (b. 1927) |
| 46707 | April 22 | Death | 2013 – Dave Gold, American businessman, founded 99 Cents Only Stores (b. 1932) |
| 46708 | April 22 | Death | 2013 – George Stanley Gordon, American businessman (b. 1926) |
| 46709 | April 22 | Death | 2013 – Richie Havens, American singer-songwriter and guitarist (b. 1941) |
| 46710 | April 22 | Death | 2013 – Lalgudi Jayaraman, Indian violinist and composer (b. 1930) |