| 48631 | April 27 | Death | 1404 – Philip the Bold, French son of John II of France (b. 1342) |
| 48632 | April 27 | Death | 1463 – Isidore of Kiev (b. 1385) |
| 48633 | April 27 | Death | 1521 – Ferdinand Magellan, Portuguese sailor and explorer (b. 1480) |
| 48634 | April 27 | Death | 1599 – Maeda Toshiie, Japanese general (b. 1538) |
| 48635 | April 27 | Death | 1605 – Pope Leo XI (b. 1535) |
| 48636 | April 27 | Death | 1613 – Robert Abercromby, Scottish priest and missionary (b. 1532) |
| 48637 | April 27 | Death | 1656 – Jan van Goyen, Dutch painter and illustrator (b. 1596) |
| 48638 | April 27 | Death | 1694 – John George IV, Elector of Saxony (b. 1668) |
| 48639 | April 27 | Death | 1695 – John Trenchard, English politician, Secretary of State for the Northern Department (b. 1640) |
| 48640 | April 27 | Death | 1702 – Jean Bart, French admiral (b. 1651) |
| 48641 | April 27 | Death | 1782 – William Talbot, 1st Earl Talbot, English politician, Lord Steward of the Household (b. 1710) |
| 48642 | April 27 | Death | 1813 – Zebulon Pike, American general and explorer (b. 1779) |
| 48643 | April 27 | Death | 1873 – William Macready, English actor and manager (b. 1793) |
| 48644 | April 27 | Death | 1882 – Ralph Waldo Emerson, American philosopher, poet, and academic (b. 1803) |
| 48645 | April 27 | Death | 1896 – Henry Parkes, English-Australian businessman and politician, 7th Premier of New South Wales (b. 1815) |
| 48646 | April 27 | Death | 1915 – John Labatt, Canadian businessman (b. 1838) |
| 48647 | April 27 | Death | 1915 – Alexander Scriabin, Russian pianist and composer (b. 1872) |
| 48648 | April 27 | Death | 1919 – Anton Irv, Estonian captain (b. 1886) |
| 48649 | April 27 | Death | 1932 – Hart Crane, American poet and author (b. 1899) |
| 48650 | April 27 | Death | 1936 – Karl Pearson, English mathematician and academic (b. 1857) |
| 48651 | April 27 | Death | 1937 – Antonio Gramsci, Italian sociologist, linguist, and politician (b. 1891) |
| 48652 | April 27 | Death | 1938 – Edmund Husserl, Czech mathematician and philosopher (b. 1859) |
| 48653 | April 27 | Death | 1952 – Guido Castelnuovo, Italian mathematician and statistician (b. 1865) |
| 48654 | April 27 | Death | 1961 – Roy Del Ruth, American director, producer, and screenwriter (b. 1893) |
| 48655 | April 27 | Death | 1962 – A. K. Fazlul Huq, Bangladeshi-Pakistani lawyer and politician, Pakistani Minister of the Interior (b. 1873) |
| 48656 | April 27 | Death | 1965 – Edward R. Murrow, American journalist (b. 1908) |
| 48657 | April 27 | Death | 1967 – William Douglas Cook, New Zealand farmer, founded the Eastwoodhill Arboretum (b. 1884) |
| 48658 | April 27 | Death | 1969 – René Barrientos, Bolivian soldier, pilot, and politician, 55th President of Bolivia (b. 1919) |
| 48659 | April 27 | Death | 1970 – Arthur Shields, Irish-American actor (b. 1896) |
| 48660 | April 27 | Death | 1972 – Kwame Nkrumah, Ghanaian politician, 1st President of Ghana (b. 1909) |