| 48721 | April 28 | Event | 1253 – Nichiren, a Japanese Buddhist monk, propounds Namu Myōhō Renge Kyō for the very first time and declares it to be the essence of Buddhism, in effect founding Nichiren Buddhism. |
| 48722 | April 28 | Event | 1503 – The Battle of Cerignola is fought. It is noted as the first battle in history won by small arms fire using gunpowder. |
| 48723 | April 28 | Event | 1611 – Establishment of the Pontifical and Royal University of Santo Tomas, The Catholic University of the Philippines, the largest Catholic university in the world. |
| 48724 | April 28 | Event | 1788 – Maryland becomes the seventh state to ratify the Constitution of the United States. |
| 48725 | April 28 | Event | 1789 – Mutiny on the Bounty: Lieutenant William Bligh and 18 sailors are set adrift and the rebel crew returns to Tahiti briefly and then sets sail for Pitcairn Island. |
| 48726 | April 28 | Event | 1792 – France invades the Austrian Netherlands (present day Belgium), beginning the French Revolutionary War. |
| 48727 | April 28 | Event | 1796 – The Armistice of Cherasco is signed by Napoleon Bonaparte and Vittorio Amedeo III, the King of Sardinia, expanding French territory along the Mediterranean coast. |
| 48728 | April 28 | Event | 1869 – Chinese and Irish laborers for the Central Pacific Railroad working on the First Transcontinental Railroad lay ten miles of track in one day, a feat which has never been matched. |
| 48729 | April 28 | Event | 1881 – Billy the Kid escapes from the Lincoln County jail in Mesilla, New Mexico. |
| 48730 | April 28 | Event | 1887 – A week after being arrested by the Prussian Secret Police, Alsatian police inspector Guillaume Schnaebelé is released on order of William I, German Emperor, defusing a possible war. |
| 48731 | April 28 | Event | 1910 – Frenchman Louis Paulhan wins the 1910 London to Manchester air race, the first long-distance aeroplane race in England. |
| 48732 | April 28 | Event | 1920 – Azerbaijan is added to the Soviet Union. |
| 48733 | April 28 | Event | 1930 – The first night game in the history of Organized Baseball took place in Independence, Kansas under permanent lights.[1] |
| 48734 | April 28 | Event | 1932 – A vaccine for yellow fever is announced for use on humans. |
| 48735 | April 28 | Event | 1944 – World War II: Nine German E-boats attacked US and UK units during Exercise Tiger, the rehearsal for the Normandy landings, killing 946. |
| 48736 | April 28 | Event | 1945 – Benito Mussolini and his mistress Clara Petacci are executed by a firing squad consisting of members of the Italian resistance movement. |
| 48737 | April 28 | Event | 1947 – Thor Heyerdahl and five crew mates set out from Peru on the Kon-Tiki to prove that Peruvian natives could have settled Polynesia. |
| 48738 | April 28 | Event | 1948 – Igor Stravinsky conducted the premier of his American ballet, Orpheus, in New York City at New York City Center. |
| 48739 | April 28 | Event | 1949 – The Hukbalahap are accused of assassinating former First Lady of the Philippines Aurora Quezon, while she is en route to dedicate a hospital in memory of her late husband her daughter and ten others are also killed. |
| 48740 | April 28 | Event | 1950 – Bhumibol Adulyadej marries Queen Sirikit after their quiet engagement in Lausanne, Switzerland on July 19, 1949. |
| 48741 | April 28 | Event | 1952 – Dwight D. Eisenhower resigns as Supreme Allied Commander of NATO. |
| 48742 | April 28 | Event | 1952 – Occupied Japan: The United States occupation of Japan ends as the Treaty of San Francisco, ratified September 8, 1951, comes into force. |
| 48743 | April 28 | Event | 1952 – The Sino-Japanese Peace Treaty (Treaty of Taipei) is signed in Taipei, Taiwan between Japan and the Republic of China to officially end the Second Sino-Japanese War. |
| 48744 | April 28 | Event | 1965 – United States occupation of the Dominican Republic: American troops land in the Dominican Republic to "forestall establishment of a Communist dictatorship" and to evacuate U.S. Army troops. |
| 48745 | April 28 | Event | 1969 – Charles de Gaulle resigns as President of France. |
| 48746 | April 28 | Event | 1970 – Vietnam War: U.S. President Richard M. Nixon formally authorizes American combat troops to fight communist sanctuaries in Cambodia. |
| 48747 | April 28 | Event | 1975 – General Cao Văn Viên, chief of the South Vietnamese military, departs for the US as the North Vietnamese Army closed in on victory. |
| 48748 | April 28 | Event | 1977 – The Red Army Faction trial ends, with Andreas Baader, Gudrun Ensslin and Jan-Carl Raspe found guilty of four counts of murder and more than 30 counts of attempted murder. |
| 48749 | April 28 | Event | 1977 – The Budapest Treaty on the International Recognition of the Deposit of Microorganisms for the Purposes of Patent Procedure is signed. |
| 48750 | April 28 | Event | 1978 – President of Afghanistan, Mohammed Daoud Khan, is overthrown and assassinated in a coup led by pro-communist rebels. |