| 58261 | May.21 | Birth | 1988 – Jonny Howson, English footballer |
| 58262 | May.21 | Birth | 1988 – Kaire Leibak, Estonian triple jumper |
| 58263 | May.21 | Birth | 1989 – Emily Robins, New Zealand actress and singer |
| 58264 | May.21 | Birth | 1989 – Hal Robson-Kanu, English footballer |
| 58265 | May.21 | Birth | 1991 – Guilherme, Brazilian footballer |
| 58266 | May.21 | Birth | 1991 – Sarah Ramos, American actress |
| 58267 | May.21 | Birth | 1992 – Hutch Dano, American actor |
| 58268 | May.21 | Birth | 1992 – Philipp Grüneberg, German footballer |
| 58269 | May.21 | Birth | 1992 – Olivia Olson, American actress and singer |
| 58270 | May.21 | Birth | 1993 – Grete Gaim, Estonian biathlete |
| 58271 | May.21 | Birth | 1993 – Luke Garbutt, English footballer |
| 58272 | May.21 | Birth | 1994 – Tom Daley, English diver |
| 58273 | May.21 | Birth | 1996 – Indy de Vroome, Dutch tennis player |
| 58274 | May.21 | Birth | 1997 – Viktoria Petryk, Ukrainian singer-songwriter |
| 58275 | May.21 | Death | 987 – Louis V of France (b. 967) |
| 58276 | May.21 | Death | 1237 – Olaf the Black, Manx son of Godred II Olafsson |
| 58277 | May.21 | Death | 1254 – Conrad IV of Germany (b. 1228) |
| 58278 | May.21 | Death | 1471 – Henry VI of England (b. 1421) |
| 58279 | May.21 | Death | 1481 – Christian I of Denmark (b. 1426) |
| 58280 | May.21 | Death | 1512 – Pandolfo Petrucci, Italian ruler (b. 1452) |
| 58281 | May.21 | Death | 1524 – Thomas Howard, 2nd Duke of Norfolk, English soldier and politician, Lord High Treasurer (b. 1443) |
| 58282 | May.21 | Death | 1542 – Hernando de Soto, Spanish-American explorer (b. 1496) |
| 58283 | May.21 | Death | 1607 – John Rainolds, English scholar and academic (b. 1549) |
| 58284 | May.21 | Death | 1639 – Tommaso Campanella, Italian astrologer, theologian, and poet (b. 1568) |
| 58285 | May.21 | Death | 1647 – Pieter Corneliszoon Hooft, Dutch poet and playwright (b. 1581) |
| 58286 | May.21 | Death | 1650 – James Graham, 1st Marquess of Montrose, Scottish general and politician (b. 1612) |
| 58287 | May.21 | Death | 1664 – Elizabeth Poole, English-American settler, founded Taunton, Massachusetts (b. 1588) |
| 58288 | May.21 | Death | 1670 – Niccolò Zucchi, Italian astronomer and physicist (b. 1586) |
| 58289 | May.21 | Death | 1690 – John Eliot, English-American minister and missionary (b. 1604) |
| 58290 | May.21 | Death | 1719 – Pierre Poiret, French mystic and philosopher (b. 1646) |