| 105391 | September 15 | Event | 1963 – 16th Street Baptist Church bombing: Four children killed at an African-American church in Birmingham, Alabama, United States |
| 105392 | September 15 | Event | 1966 – U.S. President Lyndon B. Johnson, responding to a sniper attack at the University of Texas at Austin, writes a letter to Congress urging the enactment of gun control legislation. |
| 105393 | September 15 | Event | 1968 – The Soviet Zond 5 spaceship is launched, becoming the first spacecraft to fly around the Moon and re-enter the Earth's atmosphere. |
| 105394 | September 15 | Event | 1971 – The first Greenpeace ship set sail to protest against nuclear testing. |
| 105395 | September 15 | Event | 1972 – A Scandinavian Airlines System domestic flight from Gothenburg to Stockholm is hijacked and flown to Malmö Bulltofta Airport. |
| 105396 | September 15 | Event | 1974 – Air Vietnam Flight 706 is hijacked, then crashes while attempting to land with 75 on board. |
| 105397 | September 15 | Event | 1975 – The French department of "Corse" (the entire island of Corsica) is divided into two: Haute-Corse (Upper Corsica) and Corse-du-Sud (Southern Corsica) |
| 105398 | September 15 | Event | 1978 – Muhammad Ali outpointed Leon Spinks in a rematch to become the first boxer to win the world heavyweight title three times at the Superdome in New Orleans. |
| 105399 | September 15 | Event | 1981 – The Senate Judiciary Committee unanimously approves Sandra Day O'Connor to become the first female justice of the Supreme Court of the United States |
| 105400 | September 15 | Event | 1981 – The John Bull becomes the oldest operable steam locomotive in the world when the Smithsonian Institution operates it under its own power outside Washington, D.C. |
| 105401 | September 15 | Event | 1981 – Vanuatu becomes a member of the United Nations. |
| 105402 | September 15 | Event | 1983 – Israeli premier Menachem Begin resigns. |
| 105403 | September 15 | Event | 1987 – United States Secretary of State George Shultz and Soviet Foreign Minister Eduard Shevardnadze sign a treaty to establish centers to reduce the risk of nuclear war. |
| 105404 | September 15 | Event | 1990 – France announces it will send 4,000 troops to the Persian Gulf. |
| 105405 | September 15 | Event | 1998 – With the landmark merger of WorldCom and MCI Communications completed the day prior, the new MCI WorldCom opens its doors for business. |
| 105406 | September 15 | Event | 2000 – The opening ceremony of the 2000 Summer Olympics were held in Sydney, Australia. |
| 105407 | September 15 | Event | 2004 – National Hockey League commissioner Gary Bettman announces lockout of the players' union and cessation of operations by the NHL head office. |
| 105408 | September 15 | Event | 2008 – Lehman Brothers files for Chapter 11 bankruptcy, the largest bankruptcy filing in U.S. history. |
| 105409 | September 15 | Event | 2012 – Muslim protesters shouting anti-American slogans clash with police, injuring 19 people, outside the US embassy in Sydney, Australia. |
| 105410 | September 15 | Birth | 767 – Saichō, Japanese monk (d. 822) |
| 105411 | September 15 | Birth | 786 – Al-Ma'mun, Iraqi caliph (d. 833) |
| 105412 | September 15 | Birth | 1254 – Marco Polo, Italian merchant and explorer (d. 1324) |
| 105413 | September 15 | Birth | 1533 – Catherine of Austria, Queen of Poland (d. 1572) |
| 105414 | September 15 | Birth | 1580 – Charles Annibal Fabrot, French lawyer and author (d. 1659) |
| 105415 | September 15 | Birth | 1613 – François de La Rochefoucauld, French soldier and author (d. 1680) |
| 105416 | September 15 | Birth | 1649 – Titus Oates, English minister, fabricated the Popish Plot (d. 1705) |
| 105417 | September 15 | Birth | 1666 – Sophia Dorothea of Celle (d. 1726) |
| 105418 | September 15 | Birth | 1690 – Ignazio Prota, Italian composer and educator (d. 1748) |
| 105419 | September 15 | Birth | 1715 – Jean-Baptiste Vaquette de Gribeauval, French general and engineer (d. 1789) |
| 105420 | September 15 | Birth | 1736 – Jean Sylvain Bailly, French astronomer, mathematician, and politician, 1st Mayor of Paris (d. 1793) |