| 108031 | September 21 | Birth | 1760 – Ivan Dmitriev, Russian poet and politician, Minister of Justice for Imperial Russia (d. 1837) |
| 108032 | September 21 | Birth | 1819 – Princess Louise Marie Thérèse of Artois (d. 1864) |
| 108033 | September 21 | Birth | 1840 – Murad V, Ottoman sultan (d. 1904) |
| 108034 | September 21 | Birth | 1846 – Mihály Kolossa, Hungarian-Slovene author and poet (d. 1906) |
| 108035 | September 21 | Birth | 1849 – Maurice Barrymore, Indian-American actor (d. 1905) |
| 108036 | September 21 | Birth | 1853 – Heike Kamerlingh Onnes, Dutch physicist and academic, Nobel Prize laureate (d. 1926) |
| 108037 | September 21 | Birth | 1859 – Francesc Macià i Llussà, Catalan colonel and politician, 122nd President of Catalonia (d. 1933) |
| 108038 | September 21 | Birth | 1860 – Wilson Kettle, Canadian centenarian (d. 1963) |
| 108039 | September 21 | Birth | 1862 – James E. Talmage, English-American religious leader and author (d. 1933) |
| 108040 | September 21 | Birth | 1863 – John Bunny, American actor (d. 1915) |
| 108041 | September 21 | Birth | 1866 – Charles Nicolle, French-Tunisian microbiologist and academic, Nobel Prize laureate (d. 1936) |
| 108042 | September 21 | Birth | 1866 – H. G. Wells, English historian, author, and critic (d. 1946) |
| 108043 | September 21 | Birth | 1867 – Henry L. Stimson, American colonel, lawyer, and politician, 46th United States Secretary of State (d. 1950) |
| 108044 | September 21 | Birth | 1872 – Henry Tingle Wilde, English chief officer on the RMS Titanic (d. 1912) |
| 108045 | September 21 | Birth | 1873 – Papa Jack Laine, American drummer and bandleader (d. 1966) |
| 108046 | September 21 | Birth | 1874 – Gustav Holst, English composer and educator (d. 1934) |
| 108047 | September 21 | Birth | 1878 – Peter McWilliam, Scottish-English footballer and manager (d. 1951) |
| 108048 | September 21 | Birth | 1882 – Geevarghese Ivanios, Indian metropolitan (d. 1953) |
| 108049 | September 21 | Birth | 1884 – Dénes Kőnig, Hungarian mathematician and theorist (d. 1944) |
| 108050 | September 21 | Birth | 1890 – Max Immelmann, German lieutenant and pilot (d. 1916) |
| 108051 | September 21 | Birth | 1890 – Charles William Train, English sergeant, Victoria Cross recipient (d. 1965) |
| 108052 | September 21 | Birth | 1892 – Olof Ås, Swedish actor and production manager (d. 1949) |
| 108053 | September 21 | Birth | 1894 – Anton Piëch, Austrian lawyer and businessman (d. 1952) |
| 108054 | September 21 | Birth | 1896 – Walter Breuning, American super-centenarian (d. 2011) |
| 108055 | September 21 | Birth | 1899 – Frederick Coutts, Scottish 8th General of The Salvation Army (d. 1986) |
| 108056 | September 21 | Birth | 1902 – Luis Cernuda, Spanish poet and critic (d. 1963) |
| 108057 | September 21 | Birth | 1902 – Allen Lane, English publisher, founded Penguin Books (d. 1970) |
| 108058 | September 21 | Birth | 1902 – Howie Morenz, Canadian ice hockey player (d. 1937) |
| 108059 | September 21 | Birth | 1903 – Preston Tucker, American engineer and businessman, designed the Tucker Sedan (d. 1956) |
| 108060 | September 21 | Birth | 1905 – Robert Lebel, Canadian businessman and politician (d. 1999) |