| 108112 | September 21 | Birth | 1941 – R. James Woolsey, Jr., American scholar and diplomat, 16th Director of Central Intelligence |
| 108113 | September 21 | Birth | 1942 – U-Roy, Jamaican singer-songwriter and DJ |
| 108114 | September 21 | Birth | 1942 – Sam McDowell, American baseball player |
| 108115 | September 21 | Birth | 1944 – Steve Beshear, American lawyer and politician, 61st Governor of Kentucky |
| 108116 | September 21 | Birth | 1944 – Marcus Binney, English historian and author |
| 108117 | September 21 | Birth | 1944 – Fannie Flagg, American actress and author |
| 108118 | September 21 | Birth | 1944 – Hamilton Jordan, American politician, 8th White House Chief of Staff (d. 2008) |
| 108119 | September 21 | Birth | 1944 – Bobby Tench, English singer-songwriter and guitarist (Gass, Hummingbird, Humble Pie, and Streetwalkers) |
| 108120 | September 21 | Birth | 1945 – Jerry Bruckheimer, American film and television producer |
| 108091 | September 21 | Birth | 1930 – Bob Stokoe, English footballer and manager (d. 2004) |
| 108092 | September 21 | Birth | 1931 – Larry Hagman, American actor, director, and producer (d. 2012) |
| 108093 | September 21 | Birth | 1932 – Shirley Conran, English journalist and author |
| 108094 | September 21 | Birth | 1932 – Don Preston, American keyboard player and composer (The Mothers of Invention) |
| 108095 | September 21 | Birth | 1933 – Allan Jeans, Australian footballer and coach (d. 2011) |
| 108096 | September 21 | Birth | 1933 – Dick Simon, American race car driver |
| 108097 | September 21 | Birth | 1934 – Leonard Cohen, Canadian singer-songwriter and poet |
| 108098 | September 21 | Birth | 1935 – Jimmy Armfield, English footballer and manager |
| 108099 | September 21 | Birth | 1935 – Henry Gibson, American actor and singer (d. 2009) |
| 108100 | September 21 | Birth | 1936 – Ian Albery, English manager and producer |
| 108101 | September 21 | Birth | 1936 – Dickey Lee, American singer-songwriter and guitarist |
| 108102 | September 21 | Birth | 1936 – Yury Luzhkov, Russian soldier and politician, 2nd Mayor of Moscow |
| 108103 | September 21 | Birth | 1936 – Sunny Murray, American drummer |
| 108104 | September 21 | Birth | 1936 – Diane Rehm, American journalist and radio host |
| 108105 | September 21 | Birth | 1937 – John D'Amico, Canadian ice hockey player and referee (d. 2005) |
| 108106 | September 21 | Birth | 1938 – Doug Moe, American basketball player and coach |
| 108107 | September 21 | Birth | 1939 – Agnivesh, Indian philosopher, academic, and politician |
| 108108 | September 21 | Birth | 1940 – Ron Fenton, English footballer, coach, and manager (d. 2013) |
| 108109 | September 21 | Birth | 1940 – Hermann Knoflacher, Austrian engineer and academic |
| 108110 | September 21 | Birth | 1940 – Bill Kurtis, American journalist and producer |
| 108111 | September 21 | Birth | 1941 – Jack Brisco, American wrestler and manager (d. 2010) |