| 108121 | September 21 | Birth | 1945 – G. C. Cameron, American singer (The Spinners and The Temptations) |
| 108122 | September 21 | Birth | 1945 – Richard Childress, American race car driver and businessman |
| 108123 | September 21 | Birth | 1945 – Shaw Clifton, Irish 18th General of The Salvation Army |
| 108124 | September 21 | Birth | 1945 – Kay Ryan, American poet and educator |
| 108125 | September 21 | Birth | 1946 – Rose Garrard, English sculptor and author |
| 108126 | September 21 | Birth | 1946 – Moritz Leuenberger, Swiss lawyer and politician, 87th President of the Swiss Confederation |
| 108127 | September 21 | Birth | 1946 – Ed Nimmervoll, Austrian-Australian journalist, historian, and author (d. 2014) |
| 108128 | September 21 | Birth | 1946 – Mart Siimann, Estonian psychologist and politician, 12th Prime Minister of Estonia |
| 108129 | September 21 | Birth | 1947 – Don Felder, American guitarist and songwriter (Eagles) |
| 108130 | September 21 | Birth | 1947 – Keith Harris, English ventriloquist and singer (d. 2015) |
| 108131 | September 21 | Birth | 1947 – Stephen King, American author and screenwriter |
| 108132 | September 21 | Birth | 1947 – Marsha Norman, American playwright and author |
| 108133 | September 21 | Birth | 1948 – Jack Dromey, English union leader and politician |
| 108134 | September 21 | Birth | 1949 – Henry Butler, American pianist and photographer |
| 108135 | September 21 | Birth | 1949 – Artis Gilmore, American basketball player and radio host |
| 108136 | September 21 | Birth | 1949 – Yusaku Matsuda, Japanese actor (d. 1989) |
| 108137 | September 21 | Birth | 1949 – Odilo Scherer, Brazilian cardinal |
| 108138 | September 21 | Birth | 1950 – Charles Clarke, English economist and politician, Secretary of State for Education |
| 108139 | September 21 | Birth | 1950 – Bill Murray, American actor, producer, and screenwriter |
| 108140 | September 21 | Birth | 1951 – Bruce Arena, American soccer player and manager |
| 108141 | September 21 | Birth | 1951 – DeWayne Jessie, American actor |
| 108142 | September 21 | Birth | 1951 – Aslan Maskhadov, Chechen general and politician, 3rd President of the Chechen Republic of Ichkeria (d. 2005) |
| 108143 | September 21 | Birth | 1952 – Dave Gregory, English guitarist and keyboard player (XTC and Big Big Train) |
| 108144 | September 21 | Birth | 1952 – Anneliese Michel, German woman believed to be possessed by demons (d. 1976) |
| 108145 | September 21 | Birth | 1952 – John Taylor, Baron Taylor of Warwick, English lawyer and politician |
| 108146 | September 21 | Birth | 1953 – Sunny Johnson, American actress (d. 1984) |
| 108147 | September 21 | Birth | 1953 – Arie Luyendyk, Dutch race car driver and sportscaster |
| 108148 | September 21 | Birth | 1954 – Shinzō Abe, Japanese lawyer and politician, 90th Prime Minister of Japan |
| 108149 | September 21 | Birth | 1954 – Thomas S. Ray, American ecologist and academic |
| 108150 | September 21 | Birth | 1954 – Phil "Philthy Animal" Taylor, English drummer (Motörhead and Waysted) |