| 108601 | September 22 | Birth | 1958 – Joan Jett, American singer-songwriter, guitarist, producer, and actress (The Runaways) |
| 108602 | September 22 | Birth | 1958 – Mark Patton, American actor |
| 108603 | September 22 | Birth | 1959 – Tai Babilonia, American figure skater and talk show host |
| 108604 | September 22 | Birth | 1959 – Saul Perlmutter, American astrophysicist, astronomer, and academic, Nobel Prize Laureate |
| 108605 | September 22 | Birth | 1960 – Scott Baio, American actor, director, and producer |
| 108606 | September 22 | Birth | 1960 – Ernest Martin, American murderer (d. 2003) |
| 108607 | September 22 | Birth | 1961 – Vince Coleman, American baseball player |
| 108608 | September 22 | Birth | 1961 – Liam Fox, Scottish physician and politician, Secretary of State for Defence |
| 108609 | September 22 | Birth | 1961 – Bonnie Hunt, American actress, producer, and screenwriter |
| 108610 | September 22 | Birth | 1961 – Diane Lemieux, Canadian lawyer and politician |
| 108611 | September 22 | Birth | 1961 – Catherine Oxenberg, American-English actress |
| 108612 | September 22 | Birth | 1961 – Michael Torke, American composer |
| 108613 | September 22 | Birth | 1962 – Normand D'Amour, Canadian actor |
| 108614 | September 22 | Birth | 1962 – Diogo Mainardi, Brazilian journalist |
| 108615 | September 22 | Birth | 1962 – Rob Stone, American actor |
| 108616 | September 22 | Birth | 1962 – Marq Torien, American singer-songwriter and guitarist (BulletBoys and Ratt) |
| 108617 | September 22 | Birth | 1964 – Paul Bonhomme, British competitive pilot |
| 108618 | September 22 | Birth | 1964 – Juha Turunen, Finnish lawyer and politician |
| 108619 | September 22 | Birth | 1964 – Ken Vandermark, American saxophonist and composer |
| 108620 | September 22 | Birth | 1965 – Dan Bucatinsky, American actor, director, producer, and screenwriter |
| 108621 | September 22 | Birth | 1965 – Andy Cairns, Irish singer-songwriter and guitarist (Therapy?) |
| 108622 | September 22 | Birth | 1965 – Andrii Deshchytsia, Ukrainian politician and diplomat, Ukrainian Minister of Foreign Affairs |
| 108623 | September 22 | Birth | 1965 – Tony Drago, Maltese snooker player |
| 108624 | September 22 | Birth | 1965 – Mark Guthrie, American baseball player |
| 108625 | September 22 | Birth | 1965 – Robert Satcher, American physician, engineer, and astronaut |
| 108626 | September 22 | Birth | 1966 – Ruth Jones, Welsh actress, producer, and screenwriter |
| 108627 | September 22 | Birth | 1966 – Wes Platt, American game designer, created OtherSpace |
| 108628 | September 22 | Birth | 1966 – Stefan Rehn, Swedish footballer and manager |
| 108629 | September 22 | Birth | 1966 – Mike Richter, American ice hockey player |
| 108630 | September 22 | Birth | 1966 – Erdoğan Atalay, German actor and screenwriter |