| 108691 | September 22 | Birth | 1985 – Matteo Cavagna, Italian footballer |
| 108692 | September 22 | Birth | 1985 – Rima Fakih, Lebanese-American model and wrestler, Miss USA 2010 |
| 108693 | September 22 | Birth | 1985 – Faris Haroun, Belgian footballer |
| 108694 | September 22 | Birth | 1985 – Jamie Mackie, Scottish footballer |
| 108695 | September 22 | Birth | 1985 – Tatiana Maslany, Canadian actress |
| 108696 | September 22 | Birth | 1985 – Ibragim Todashev, Russian-American mixed martial artist (d. 2013) |
| 108697 | September 22 | Birth | 1987 – Derick Brassard, Canadian ice hockey player |
| 108698 | September 22 | Birth | 1987 – Stefan Denifl, Austrian cyclist |
| 108699 | September 22 | Birth | 1987 – Tom Felton, English actor and singer |
| 108700 | September 22 | Birth | 1987 – Zdravko Kuzmanović, Serbian footballer |
| 108701 | September 22 | Birth | 1987 – Alfred Rainer, Austrian soldier and skier (d. 2008) |
| 108702 | September 22 | Birth | 1988 – Nikita Andreyev, Russian footballer |
| 108703 | September 22 | Birth | 1988 – Bethany Dillon, American singer-songwriter and guitarist |
| 108704 | September 22 | Birth | 1988 – Mohamed Faisal, Maldivian footballer |
| 108705 | September 22 | Birth | 1988 – Ali Fasir, Maldivian footballer |
| 108706 | September 22 | Birth | 1989 – Cœur de pirate, Canadian singer-songwriter and pianist (Armistice and Bonjour Brumaire) |
| 108707 | September 22 | Birth | 1989 – Kim Hyo-yeon, South Korean singer, dancer, and actress (Girls' Generation) |
| 108708 | September 22 | Birth | 1989 – Sabine Lisicki, German tennis player |
| 108709 | September 22 | Birth | 1990 – Denard Robinson, American football player |
| 108710 | September 22 | Birth | 1990 – Senem Kuyucuoğlu, Turkish model and television host |
| 108711 | September 22 | Birth | 1991 – Khairul Anuar Mohamad, Malaysian archer |
| 108712 | September 22 | Birth | 1993 – Chase Ellison, American actor |
| 108713 | September 22 | Birth | 1994 – Jr., South Korean singer, dancer, and actor (Got7 and JJ Project) |
| 108714 | September 22 | Birth | 1994 – Ralf Tribuntsov, Estonian swimmer |
| 108715 | September 22 | Birth | 1999 – Tallan Latz, Canadian-American guitarist |
| 108716 | September 22 | Birth | 1999 – Kim Yoo-jung, South Korean actress |
| 108717 | September 22 | Death | 1072 – Ouyang Xiu, Chinese historian, poet, and politician (b. 1007) |
| 108718 | September 22 | Death | 1253 – Dōgen, Japanese monk and philosopher (b. 1200) |
| 108719 | September 22 | Death | 1345 – Henry, 3rd Earl of Lancaster, English politician, Lord High Steward (b. 1281) |
| 108720 | September 22 | Death | 1399 – Thomas de Mowbray, 1st Duke of Norfolk, English politician, Earl Marshal of The United Kingdom (b. 1366) |