| 120481 | October 21 | Birth | 1972 – Felicity Andersen, Australian actress |
| 120482 | October 21 | Birth | 1972 – Matthew Friedberger, American singer-songwriter and guitarist (The Fiery Furnaces) |
| 120483 | October 21 | Birth | 1972 – Masakazu Morita, Japanese voice actor |
| 120484 | October 21 | Birth | 1972 – Orlando Thomas, American football player (d. 2014) |
| 120485 | October 21 | Birth | 1972 – Evhen Tsybulenko, Ukrainian scholar and academic |
| 120486 | October 21 | Birth | 1973 – Lera Auerbach, Russian-American pianist and composer |
| 120487 | October 21 | Birth | 1973 – Sasha Roiz, Israeli-Canadian actor |
| 120488 | October 21 | Birth | 1973 – Charlie Lowell, American pianist and songwriter (Jars of Clay) |
| 120489 | October 21 | Birth | 1974 – Costel Busuioc, Romanian tenor |
| 120490 | October 21 | Birth | 1975 – Toby Hall, American baseball player |
| 120491 | October 21 | Birth | 1975 – Henrique Hilário, Portuguese footballer |
| 120492 | October 21 | Birth | 1976 – Henrik Gustavsson, Swedish footballer |
| 120493 | October 21 | Birth | 1976 – Jeremy Miller, American actor and singer |
| 120494 | October 21 | Birth | 1976 – Lavinia Miloșovici, Romanian gymnast |
| 120495 | October 21 | Birth | 1976 – Josh Ritter, American singer-songwriter and guitarist |
| 120496 | October 21 | Birth | 1976 – Andrew Scott, Irish actor |
| 120497 | October 21 | Birth | 1976 – Mélanie Turgeon, Canadian skier |
| 120498 | October 21 | Birth | 1977 – Julieta Cardinali, Argentinian actress |
| 120499 | October 21 | Birth | 1977 – David Clayton Rogers, American actor, producer, and screenwriter |
| 120500 | October 21 | Birth | 1978 – Will Estes, American actor |
| 120501 | October 21 | Birth | 1978 – Joey Harrington, American football player and sportscaster |
| 120502 | October 21 | Birth | 1978 – Henrik Klingenberg, Finnish singer and keyboard player (Sonata Arctica and Silent Voices) |
| 120503 | October 21 | Birth | 1979 – Khalil Greene, American baseball player |
| 120504 | October 21 | Birth | 1979 – Gabe Gross, American baseball player |
| 120505 | October 21 | Birth | 1979 – Karl Harris, English motorcycle racer (d. 2014) |
| 120506 | October 21 | Birth | 1979 – Shiho Takano, Japanese actress |
| 120507 | October 21 | Birth | 1980 – Kim Kardashian, American model, actress, and fashion designer |
| 120508 | October 21 | Birth | 1980 – Brian Pittman, American bass player (Relient K and Inhale Exhale) |
| 120509 | October 21 | Birth | 1981 – Carmella Bing, American porn actress and model |
| 120510 | October 21 | Birth | 1981 – Martin Castrogiovanni, Argentinian-Italian rugby player |