| 120661 | October 21 | Holiday and observance | International Day of the Nacho |
| 120662 | October 21 | Holiday and observance | National Nurses' Day (Thailand) |
| 120663 | October 21 | Holiday and observance | Ndadaye Day (Burundi) |
| 120664 | October 21 | Holiday and observance | Overseas Chinese Day (Republic of China) |
| 120665 | October 21 | Holiday and observance | Trafalgar Day (the British Empire in the 19th and early 20th century) |
| 120666 | October 22 | Event | 4004 BC – The world was created at approximately six o'clock in the evening, according to the Ussher chronology. |
| 120667 | October 22 | Event | 362 – The temple of Apollo at Daphne, outside Antioch, is destroyed in a mysterious fire. |
| 120668 | October 22 | Event | 451 – The Council of Chalcedon adopts the Chalcedonian Creed regarding the divine and human nature of Jesus Christ. |
| 120669 | October 22 | Event | 794 – Emperor Kanmu relocates the Japanese capital to Heiankyo (now Kyoto). |
| 120670 | October 22 | Event | 1383 – The 1383–85 Crisis in Portugal: King Fernando dies without a male heir to the Portuguese throne, sparking a period of civil war and disorder. |
| 120671 | October 22 | Event | 1575 – Foundation of Aguascalientes. |
| 120672 | October 22 | Event | 1633 – Battle of Liaoluo Bay: The Ming dynasty defeats the Dutch East India Company. |
| 120673 | October 22 | Event | 1707 – Scilly naval disaster: four British Royal Navy ships run aground near the Isles of Scilly because of faulty navigation. Admiral Sir Cloudesley Shovell and thousands of sailors drown. |
| 120674 | October 22 | Event | 1730 – Construction of the Ladoga Canal is completed. |
| 120675 | October 22 | Event | 1746 – The College of New Jersey (later renamed Princeton University) receives its charter. |
| 120676 | October 22 | Event | 1777 – American Revolutionary War: American defenders of Fort Mercer on the Delaware River repulse repeated Hessian attacks in the Battle of Red Bank. |
| 120677 | October 22 | Event | 1784 – Russia founds a colony on Kodiak Island, Alaska. |
| 120678 | October 22 | Event | 1790 – Warriors of the Miami people under Chief Little Turtle defeat United States troops under General Josiah Harmar at the site of present-day Fort Wayne, Indiana, in the Northwest Indian War. |
| 120679 | October 22 | Event | 1797 – André-Jacques Garnerin makes the first recorded parachute jump from one thousand meters (3,200 feet) above Paris. |
| 120680 | October 22 | Event | 1836 – Sam Houston is inaugurated as the first President of the Republic of Texas. |
| 120681 | October 22 | Event | 1844 – The Great Anticipation: Millerites, followers of William Miller, anticipate the end of the world in conjunction with the Second Advent of Christ. The following day became known as the Great Disappointment. |
| 120682 | October 22 | Event | 1859 – Spain declares war on Morocco. |
| 120683 | October 22 | Event | 1866 – A plebiscite ratifies the annexion of Veneto and Mantua to Italy, occurred three days before, on October 19. |
| 120684 | October 22 | Event | 1875 – First telegraphic connection in Argentina. |
| 120685 | October 22 | Event | 1877 – The Blantyre mining disaster in Scotland kills 207 miners. |
| 120686 | October 22 | Event | 1878 – The first rugby match under floodlights takes place in Salford, between Broughton and Swinton. |
| 120687 | October 22 | Event | 1879 – Using a filament of carbonized thread, Thomas Edison tests the first practical electric incandescent light bulb (it lasted 13½ hours before burning out). |
| 120688 | October 22 | Event | 1883 – The Metropolitan Opera House in New York City opens with a performance of Gounod's Faust. |
| 120689 | October 22 | Event | 1884 – Greenwich, in London, England, is adopted as Universal Time meridian of longitude by the International Meridian Conference. |
| 120690 | October 22 | Event | 1895 – In Paris an express train derails after overrunning the buffer stop, crossing almost 30 metres (100 ft) of concourse before crashing through a wall and falling 10 metres (33 ft) to the road below. |