| 120691 | October 22 | Event | 1907 – Panic of 1907: A run on the stock of the Knickerbocker Trust Company sets events in motion that will lead to a depression. |
| 120692 | October 22 | Event | 1910 – Dr. Crippen is convicted at the Old Bailey of poisoning his wife and is subsequently hanged at Pentonville Prison in London. |
| 120693 | October 22 | Event | 1923 – The royalist Leonardopoulos–Gargalidis coup d'état attempt fails in Greece, discrediting the monarchy and paving the way for the establishment of the Second Hellenic Republic. |
| 120694 | October 22 | Event | 1924 – Toastmasters International is founded. |
| 120695 | October 22 | Event | 1926 – J. Gordon Whitehead sucker punches magician Harry Houdini in the stomach in Montreal, precipitating his death. |
| 120696 | October 22 | Event | 1927 – Nikola Tesla introduces six new inventions including a motor with onephase electricity |
| 120697 | October 22 | Event | 1928 – Phi Sigma Alpha fraternity is founded at the University of Puerto Rico, Río Piedras Campus. |
| 120698 | October 22 | Event | 1934 – In East Liverpool, Ohio, Federal Bureau of Investigation agents shoot and kill notorious bank robber Pretty Boy Floyd. |
| 120699 | October 22 | Event | 1941 – World War II: French resistance member Guy Môquet and 29 other hostages are executed by the Germans in retaliation for the death of a German officer. |
| 120700 | October 22 | Event | 1943 – World War II: in the Second firestorm raid on Germany, the Royal Air Force conducts an air raid on the town of Kassel, killing 10,000 and rendering 150,000 homeless. |
| 120701 | October 22 | Event | 1946 – Soviet Operation Osoaviakhim takes place, recruiting of thousands of military-related technical specialists from the Soviet occupation zone of post-World-War-II Germany for employment in the Soviet Union. |
| 120702 | October 22 | Event | 1957 – Vietnam War: First United States casualties in Vietnam. |
| 120703 | October 22 | Event | 1962 – Cuban Missile Crisis: US President John F. Kennedy, after internal counsel from Dwight D. Eisenhower, announces that American reconnaissance planes have discovered Soviet nuclear weapons in Cuba, and that he has ordered a naval "quarantine" of the |
| 120704 | October 22 | Event | 1963 – A BAC One-Eleven prototype airliner crashes in UK with the loss of all on board. |
| 120705 | October 22 | Event | 1964 – Jean-Paul Sartre is awarded the Nobel Prize in Literature, but turns down the honor. |
| 120706 | October 22 | Event | 1964 – Canada: A Multi-Party Parliamentary Committee selects the design which becomes the new official flag of Canada. |
| 120707 | October 22 | Event | 1966 – The Supremes become the first all-female music group to attain a No. 1 selling album (The Supremes A' Go-Go). |
| 120708 | October 22 | Event | 1966 – The Soviet Union launches Luna 12. |
| 120709 | October 22 | Event | 1968 – Apollo program: Apollo 7 safely splashes down in the Atlantic Ocean after orbiting the Earth 163 times. |
| 120710 | October 22 | Event | 1972 – Vietnam War: In Saigon, Henry Kissinger and South Vietnamese President Nguyễn Văn Thiệu meet to discuss a proposed cease-fire that had been worked out between Americans and North Vietnamese in Paris. |
| 120711 | October 22 | Event | 1973 – United Nations Security Council Resolution 338 calling for ceasefire of Yom Kippur War is adopted. |
| 120712 | October 22 | Event | 1975 – The Soviet unmanned space mission Venera 9 lands on Venus. |
| 120713 | October 22 | Event | 1976 – Red Dye No. 4 is banned by the US Food and Drug Administration after it is discovered that it causes tumors in the bladders of dogs. The dye is still used in Canada. |
| 120714 | October 22 | Event | 1978 – Papal inauguration of Pope John Paul II. |
| 120715 | October 22 | Event | 1981 – The United States Federal Labor Relations Authority votes to decertify the Professional Air Traffic Controllers Organization for its strike the previous August. |
| 120716 | October 22 | Event | 1983 – Two correctional officers are killed by inmates at the United States Penitentiary in Marion, Illinois. The incident inspires the Supermax model of prisons. |
| 120717 | October 22 | Event | 1989 – 11-year-old Jacob Wetterling is kidnapped by a masked gunman as he rode his bike near his home in St. Joseph, Minnesota. |
| 120718 | October 22 | Event | 1999 – Maurice Papon, an official in the Vichy France government during World War II, is jailed for crimes against humanity. |
| 120719 | October 22 | Event | 2001 – Grand Theft Auto III was released, popularizing a genre of open-world, action-adventure video games as well as spurring controversy around violence in video games. |
| 120720 | October 22 | Event | 2005 – Tropical Storm Alpha forms in the Atlantic Basin, making the 2005 Atlantic hurricane season the most active Atlantic hurricane season on record with 22 named storms. |