| 120721 | October 22 | Event | 2006 – A Panama Canal expansion proposal is approved by 77.8% of voters in a National referendum held in Panama. |
| 120722 | October 22 | Event | 2007 – Raid on Anuradhapura Air Force Base is carried out by 21 Tamil Tiger commandos. All except one died in this attack. Eight Sri Lanka Air Force planes are destroyed and 10 damaged. |
| 120723 | October 22 | Event | 2008 – India launches its first unmanned lunar mission Chandrayaan-1. |
| 120724 | October 22 | Event | 2013 – The Australian Capital Territory becomes the first Australian jurisdiction to legalize same-sex marriage with the Marriage Equality (Same Sex) Act 2013 |
| 120725 | October 22 | Event | 2014 – Michael Zehaf-Bibeau attacks the Parliament of Canada in Ottawa, Canada, killing a soldier and injuring three other people. |
| 120726 | October 22 | Event | 2015 – A teacher and a student are killed, and 2 students injured, in an attack at a high school in Trollhättan, Sweden. |
| 120727 | October 22 | Birth | 1071 – William IX, Duke of Aquitaine (d. 1126) |
| 120728 | October 22 | Birth | 1197 – Emperor Juntoku of Japan (d. 1242) |
| 120729 | October 22 | Birth | 1511 – Erasmus Reinhold, German astronomer and mathematician (d. 1553) |
| 120730 | October 22 | Birth | 1592 – Gustav Horn, Count of Pori (d. 1657) |
| 120731 | October 22 | Birth | 1659 – Georg Ernst Stahl, German chemist and physician (d. 1734) |
| 120732 | October 22 | Birth | 1689 – John V of Portugal (d. 1750) |
| 120733 | October 22 | Birth | 1701 – Maria Amalia of Austria (d. 1756) |
| 120734 | October 22 | Birth | 1729 – Johann Reinhold Forster, German pastor and botanist (d. 1798) |
| 120735 | October 22 | Birth | 1734 – Daniel Boone, American hunter and explorer (d. 1820) |
| 120736 | October 22 | Birth | 1749 – Cornelis van der Aa, Dutch historian and bookseller (d. 1816) |
| 120737 | October 22 | Birth | 1809 – Volney Howard, American lawyer, jurist, and politician, Texas Attorney General (d. 1889) |
| 120738 | October 22 | Birth | 1811 – Franz Liszt, Hungarian pianist and composer (d. 1886) |
| 120739 | October 22 | Birth | 1818 – Leconte de Lisle, French poet and author (d. 1894) |
| 120740 | October 22 | Birth | 1821 – Collis Potter Huntington, American businessman (d. 1900) |
| 120741 | October 22 | Birth | 1832 – August Labitzky, Czech composer and conductor (d. 1903) |
| 120742 | October 22 | Birth | 1844 – Sarah Bernhardt, French actress and manager (d. 1923) |
| 120743 | October 22 | Birth | 1844 – Louis Riel, Canadian scholar and politician (d. 1885) |
| 120744 | October 22 | Birth | 1847 – Koos de la Rey, South African general (d. 1914) |
| 120745 | October 22 | Birth | 1858 – Augusta Victoria of Schleswig-Holstein (d. 1921) |
| 120746 | October 22 | Birth | 1865 – Kristjan Raud, Estonian painter and illustrator (d. 1943) |
| 120747 | October 22 | Birth | 1870 – Ivan Bunin, Russian author and poet, Nobel Prize laureate (d. 1953) |
| 120748 | October 22 | Birth | 1870 – Lord Alfred Douglas, English author and poet (d. 1945) |
| 120749 | October 22 | Birth | 1873 – Gustaf John Ramstedt, Finnish linguist and diplomat (d. 1950) |
| 120750 | October 22 | Birth | 1873 – Rama Tirtha, Indian philosopher and educator (d. 1906) |