| 121951 | October 25 | Event | 1977 – Digital Equipment Corporation releases OpenVMS V1.0. |
| 121952 | October 25 | Event | 1980 – Proceedings on the Hague Convention on the Civil Aspects of International Child Abduction conclude at The Hague. |
| 121953 | October 25 | Event | 1983 – Operation Urgent Fury: The United States and its Caribbean allies invade Grenada, six days after Prime Minister Maurice Bishop and several of his supporters are executed in a coup d'état. |
| 121954 | October 25 | Event | 1995 – A commuter train slams into a school bus in Fox River Grove, Illinois, killing seven students. |
| 121955 | October 25 | Event | 1997 – After a brief civil war which has driven President Pascal Lissouba out of Brazzaville, Denis Sassou Nguesso proclaims himself the President of the Republic of the Congo. |
| 121956 | October 25 | Event | 2004 – Cuban President Fidel Castro announces that transactions using the American Dollar will be banned. |
| 121957 | October 25 | Event | 2009 – The October 2009 Baghdad bombings kills 155 and wounds at least 721. |
| 121958 | October 25 | Birth | 1102 – William Clito, French son of Sybilla of Conversano (d. 1128) |
| 121959 | October 25 | Birth | 1330 – Louis II, Count of Flanders (d. 1384) |
| 121960 | October 25 | Birth | 1510 – Renée of France (d. 1574) |
| 121961 | October 25 | Birth | 1683 – Charles FitzRoy, 2nd Duke of Grafton, English-Irish politician, Lord Lieutenant of Ireland (d. 1757) |
| 121962 | October 25 | Birth | 1709 – Georg Gebel, German organist and composer (d. 1753) |
| 121963 | October 25 | Birth | 1759 – Maria Feodorovna, Russian wife of Paul I of Russia (d. 1828) |
| 121964 | October 25 | Birth | 1759 – William Grenville, 1st Baron Grenville, English academic and politician, Prime Minister of the United Kingdom (d. 1834) |
| 121965 | October 25 | Birth | 1767 – Benjamin Constant, Swiss-French philosopher and politician (d. 1830) |
| 121966 | October 25 | Birth | 1772 – Géraud Duroc, French general and diplomat (d. 1813) |
| 121967 | October 25 | Birth | 1782 – Levi Lincoln, Jr., American lawyer and politician, 13th Governor of Massachusetts (d. 1868) |
| 121968 | October 25 | Birth | 1800 – Thomas Babington Macaulay, 1st Baron Macaulay, English poet, historian, and politician, Secretary at War (d. 1859) |
| 121969 | October 25 | Birth | 1802 – Richard Parkes Bonington, English painter (d. 1828) |
| 121970 | October 25 | Birth | 1802 – Joseph Montferrand, Canadian logger and strongman (d. 1864) |
| 121971 | October 25 | Birth | 1806 – Max Stirner, German philosopher and author (d. 1856) |
| 121972 | October 25 | Birth | 1811 – Évariste Galois, French mathematician and theorist (d. 1832) |
| 121973 | October 25 | Birth | 1815 – Camillo Sivori, Italian virtuoso violinist and composer (d. 1894) |
| 121974 | October 25 | Birth | 1825 – Johann Strauss II, Austrian composer and educator (d. 1899) |
| 121975 | October 25 | Birth | 1838 – Georges Bizet, French pianist and composer (d. 1875) |
| 121976 | October 25 | Birth | 1856 – Dragutin Gorjanović-Kramberger, Croatian geologist, paleontologist, and archaeologist (d. 1936) |
| 121977 | October 25 | Birth | 1864 – John Francis Dodge, American businessman, co-founded the Dodge Company (d. 1920) |
| 121978 | October 25 | Birth | 1864 – Alexander Gretchaninov, Russian-American pianist and composer (d. 1956) |
| 121979 | October 25 | Birth | 1867 – Józef Dowbor-Muśnicki, Polish general (d. 1937) |
| 121980 | October 25 | Birth | 1868 – Dan Burke, American baseball player (d. 1933) |