| 132271 | November 21 | Birth | 1941 – Juliet Mills, English actress |
| 132272 | November 21 | Birth | 1942 – Afa Anoaʻi, Samoan-American wrestler and manager |
| 132273 | November 21 | Birth | 1942 – Heidemarie Wieczorek-Zeul, German educator and politician |
| 132274 | November 21 | Birth | 1943 – Phil Bredesen, American businessman and politician, 48th Governor of Tennessee |
| 132275 | November 21 | Birth | 1943 – Jacques Laffite, French race car driver |
| 132276 | November 21 | Birth | 1943 – Larry Mahan, American rodeo performer |
| 132277 | November 21 | Birth | 1944 – Dick Durbin, American lawyer and politician |
| 132278 | November 21 | Birth | 1944 – Earl Monroe, American basketball player and sportscaster |
| 132279 | November 21 | Birth | 1944 – Harold Ramis, American actor, director, producer, and screenwriter (d. 2014) |
| 132280 | November 21 | Birth | 1945 – Goldie Hawn, American actress, singer, and producer |
| 132281 | November 21 | Birth | 1946 – Jacky Lafon, Belgian actress |
| 132282 | November 21 | Birth | 1947 – Nickolas Grace, English actor |
| 132283 | November 21 | Birth | 1947 – Tiny Ron Taylor, American actor and basketball player |
| 132284 | November 21 | Birth | 1948 – Lonnie Jordan, American singer-songwriter and guitarist (War) |
| 132285 | November 21 | Birth | 1948 – Alphonse Mouzon, American drummer and songwriter (Weather Report and The Eleventh House) |
| 132286 | November 21 | Birth | 1948 – Michel Suleiman, Lebanese general and politician, 16th President of Lebanon |
| 132287 | November 21 | Birth | 1948 – George Zimmer, American businessman, founded Men's Wearhouse |
| 132288 | November 21 | Birth | 1950 – Hisham Barakat, Egyptian lawyer and judge (d. 2015) |
| 132289 | November 21 | Birth | 1950 – Stephen Geyer, American composer |
| 132290 | November 21 | Birth | 1950 – Gary Pihl, American guitarist (Boston) |
| 132291 | November 21 | Birth | 1952 – Mervyn Davies, Baron Davies of Abersoch, Welsh banker and politician |
| 132292 | November 21 | Birth | 1952 – Janne Kristiansen, Norwegian lawyer and jurist |
| 132293 | November 21 | Birth | 1952 – Lorna Luft, American actress and singer |
| 132294 | November 21 | Birth | 1953 – Tina Brown, English-American journalist and author |
| 132295 | November 21 | Birth | 1954 – Thomas Rothman, American actor, producer, and screenwriter |
| 132296 | November 21 | Birth | 1954 – Fiona Pitt-Kethley, English journalist, author, and poet |
| 132297 | November 21 | Birth | 1955 – Cedric Maxwell, American basketball player, coach, and sportscaster |
| 132298 | November 21 | Birth | 1956 – Cherry Jones, American actress |
| 132299 | November 21 | Birth | 1958 – David Reivers, Jamaican-American actor and producer |
| 132300 | November 21 | Birth | 1959 – Sergei Ratnikov, Estonian footballer and manager |