| 143551 | December 21 | Birth | 1946 – Kevin Peek, Australian guitarist and songwriter (Sky) (d. 2013) |
| 143552 | December 21 | Birth | 1946 – Carl Wilson, American singer-songwriter and guitarist (The Beach Boys) (d. 1998) |
| 143553 | December 21 | Birth | 1947 – Paco de Lucía, Spanish guitarist, songwriter, and producer (Paco de Lucía Sextet) (d. 2014) |
| 143554 | December 21 | Birth | 1947 – Bryan Hamilton, Irish footballer and manager |
| 143555 | December 21 | Birth | 1948 – Samuel L. Jackson, American actor and producer |
| 143556 | December 21 | Birth | 1948 – Dave Kingman, American baseball player |
| 143557 | December 21 | Birth | 1948 – Willi Resetarits, Austrian singer-songwriter, actor, and activist |
| 143558 | December 21 | Birth | 1949 – Nicholas Penny, English historian and academic |
| 143559 | December 21 | Birth | 1949 – Thomas Sankara, Burkinabé captain and politician, 5th President of Burkina Faso (d. 1987) |
| 143560 | December 21 | Birth | 1949 – Nikolaos Sifounakis, Greek politician |
| 143561 | December 21 | Birth | 1950 – Jeffrey Katzenberg, American screenwriter and producer, co-founded DreamWorks Animation |
| 143562 | December 21 | Birth | 1950 – Lillebjørn Nilsen, Norwegian singer-songwriter and guitarist (Gitarkameratene) |
| 143563 | December 21 | Birth | 1950 – David Thacker, English director and screenwriter |
| 143564 | December 21 | Birth | 1951 – Nick Gilder, English-Canadian singer-songwriter (Sweeney Todd) |
| 143565 | December 21 | Birth | 1951 – Steve Perryman, English footballer and manager |
| 143566 | December 21 | Birth | 1952 – Joaquín Andújar, Dominican baseball player (d. 2015) |
| 143567 | December 21 | Birth | 1953 – András Schiff, Hungarian-English pianist and conductor |
| 143568 | December 21 | Birth | 1953 – Betty Wright, American singer-songwriter |
| 143569 | December 21 | Birth | 1954 – Chris Evert, American tennis player and coach |
| 143570 | December 21 | Birth | 1954 – Tsurutaro Kataoka, Japanese boxer, television personality, actor, and artist |
| 143571 | December 21 | Birth | 1955 – Jane Kaczmarek, American actress |
| 143572 | December 21 | Birth | 1955 – Kazuyuki Sekiguchi, Japanese singer-songwriter and bass player (Southern All Stars) |
| 143573 | December 21 | Birth | 1956 – Dave Laut, American shot putter (d. 2009) |
| 143574 | December 21 | Birth | 1957 – Tom Henke, American baseball player |
| 143575 | December 21 | Birth | 1957 – Rolf Kanies, German actor |
| 143576 | December 21 | Birth | 1957 – Ray Romano, American actor, producer, and screenwriter |
| 143577 | December 21 | Birth | 1958 – Tamara Bykova, Russian high jumper |
| 143578 | December 21 | Birth | 1959 – Florence Griffith Joyner, American sprinter and actress (d. 1998) |
| 143579 | December 21 | Birth | 1960 – Roger McDowell, American baseball player and coach |
| 143580 | December 21 | Birth | 1960 – Sherry Rehman, Pakistani journalist, politician, and diplomat, 25th Pakistan Ambassador to the United States |