| 143581 | December 21 | Birth | 1960 – Tim Rucks, American football player and coach (d. 2015) |
| 143582 | December 21 | Birth | 1960 – Andy Van Slyke, American baseball player and coach |
| 143583 | December 21 | Birth | 1961 – Henry Ford Kamel, Ghanaian banker and politician (d. 2012) |
| 143584 | December 21 | Birth | 1961 – Francis Ng, Hong Kong actor and director |
| 143585 | December 21 | Birth | 1961 – The Patriot, American wrestler |
| 143586 | December 21 | Birth | 1961 – Rein Raud, Estonian scholar and author |
| 143587 | December 21 | Birth | 1961 – Ryuji Sasai, Japanese bass player and composer |
| 143588 | December 21 | Birth | 1963 – Govinda, Indian actor, singer, and politician |
| 143589 | December 21 | Birth | 1964 – Rob Kelly, English footballer and manager |
| 143590 | December 21 | Birth | 1964 – Joe Kocur, Canadian ice hockey player and coach |
| 143591 | December 21 | Birth | 1964 – Kunihiko Ikuhara, Japanese director |
| 143592 | December 21 | Birth | 1964 – Daniel Suarez, American author |
| 143593 | December 21 | Birth | 1964 – Fabiana Udenio, Argentinian-Italian actress |
| 143594 | December 21 | Birth | 1965 – Andy Dick, American comedian, actor, producer, and screenwriter |
| 143595 | December 21 | Birth | 1965 – Anke Engelke, Canadian-German actress, director, and screenwriter |
| 143596 | December 21 | Birth | 1965 – Stuart Mitchell, Scottish pianist and composer |
| 143597 | December 21 | Birth | 1965 – Masahiro Motoki. Japanese actor |
| 143598 | December 21 | Birth | 1966 – Martin Bayfield, English rugby player, actor, and stuntman |
| 143599 | December 21 | Birth | 1966 – Adam Schefter, American journalist and sportscaster |
| 143600 | December 21 | Birth | 1966 – Kiefer Sutherland, English-Canadian actor, director, and producer |
| 143601 | December 21 | Birth | 1966 – Karri Turner, American actress |
| 143602 | December 21 | Birth | 1967 – Ervin Johnson, American basketball player |
| 143603 | December 21 | Birth | 1967 – Fritz Karl, Austrian actor |
| 143604 | December 21 | Birth | 1967 – Terry Mills, American basketball player and coach |
| 143605 | December 21 | Birth | 1967 – Mikheil Saakashvili, Georgian lawyer and politician, 3rd President of Georgia |
| 143606 | December 21 | Birth | 1969 – Julie Delpy, French-American model, actress, director, and screenwriter |
| 143607 | December 21 | Birth | 1969 – Jack Noseworthy, American actor |
| 143608 | December 21 | Birth | 1969 – Mihails Zemļinskis, Latvian footballer, coach, and manager |
| 143609 | December 21 | Birth | 1971 – Matthieu Chedid, French singer-songwriter and guitarist |
| 143610 | December 21 | Birth | 1971 – Margarita Drobiazko, Lithuanian ice dancer |