| 144901 | December 25 | Event | 1962 – The Soviet Union conducts its final above-ground nuclear weapon test, in anticipation of the 1963 Partial Nuclear Test Ban Treaty. |
| 144902 | December 25 | Event | 1963 – Turkish Cypriot Bayrak Radio begins transmitting in Cyprus after Turkish Cypriots are forcibly excluded from Cyprus Broadcasting Corporation. |
| 144903 | December 25 | Event | 1965 – The Yemeni Nasserist Unionist People's Organisation is founded in Ta'izz |
| 144904 | December 25 | Event | 1968 – Apollo program: Apollo 8 performs the very first successful Trans-Earth injection (TEI) maneuver, sending the crew and spacecraft on a trajectory back to Earth from Lunar orbit. |
| 144905 | December 25 | Event | 1968 – Kilvenmani massacre, 44 Dalits (untouchables) burnt to death in Kizhavenmani village, Tamil Nadu, a retaliation for a campaign for higher wages by Dalit laborers. |
| 144906 | December 25 | Event | 1974 – Cyclone Tracy devastates Darwin, Northern Territory Australia. |
| 144907 | December 25 | Event | 1974 – Marshall Fields drives a vehicle through the gates of the White House, resulting in a four-hour standoff. |
| 144908 | December 25 | Event | 1977 – Israeli Prime Minister Menachem Begin meets in Egypt with its president Anwar Sadat. |
| 144909 | December 25 | Event | 1989 – Deposed President of Romania Nicolae Ceaușescu and his wife, First-Deputy Prime-Minister Elena Ceaușescu are condemned to death and executed after a summary trial. |
| 144910 | December 25 | Event | 1991 – Mikhail Gorbachev resigns as General Secretary of the Soviet Union (the union itself is dissolved the next day). Ukraine's referendum is finalized and Ukraine officially leaves the Soviet Union. |
| 144911 | December 25 | Event | 2000 – Russian President Vladimir Putin signs a bill into law that officially establishes a new National Anthem of Russia, with music adopted from the anthem of the Soviet Union that was composed by Alexander Vasilyevich Alexandrov. |
| 144912 | December 25 | Event | 2003 – The ill-fated Beagle 2 probe, released from the Mars Express spacecraft on December 19, disappears shortly before its scheduled landing. |
| 144913 | December 25 | Event | 2004 – Cassini orbiter releases Huygens probe which successfully landed on Saturn's moon Titan on January 14, 2005. |
| 144914 | December 25 | Event | 2009 – Umar Farouk Abdulmutallab unsuccessfully attempts a terrorist attack against the US while on board a flight to Detroit Metro Airport Northwest Airlines Flight 253 |
| 144915 | December 25 | Event | 2012 – An Antonov An-72 plane crashes close to the city of Shymkent, killing 27 people. |
| 144916 | December 25 | Birth | 1250 – John IV Laskaris, Byzantine emperor (d. 1305) |
| 144917 | December 25 | Birth | 1461 – Christina of Saxony (d. 1521) |
| 144918 | December 25 | Birth | 1505 – Christine of Saxony (d. 1549) |
| 144919 | December 25 | Birth | 1583 – Orlando Gibbons, English organist and composer (d. 1625) |
| 144920 | December 25 | Birth | 1584 – Margaret of Austria, Queen of Spain (d. 1611) |
| 144921 | December 25 | Birth | 1628 – Noël Coypel, French painter (d. 1707) |
| 144922 | December 25 | Birth | 1642 – Isaac Newton, English physicist and mathematician (d. 1726/7) |
| 144923 | December 25 | Birth | 1652 – Archibald Pitcairne, Scottish physician, anatomist, and scholar (d. 1713) |
| 144924 | December 25 | Birth | 1665 – Lady Grizel Baillie, Scottish-English poet and songwriter (d. 1746) |
| 144925 | December 25 | Birth | 1667 – Melusine von der Schulenburg, Duchess of Kendal (d. 1743) |
| 144926 | December 25 | Birth | 1674 – Thomas Halyburton, Scottish minister and theologian (d. 1712) |
| 144927 | December 25 | Birth | 1686 – Giovanni Battista Somis, Italian violinist and composer (d. 1763) |
| 144928 | December 25 | Birth | 1696 – Prince Johann Ernst of Saxe-Weimar (d. 1715) |
| 144929 | December 25 | Birth | 1700 – Leopold II, Prince of Anhalt-Dessau (d. 1758) |
| 144930 | December 25 | Birth | 1711 – Jean-Joseph de Mondonville, French violinist and composer (d. 1772) |