| 145711 | December 27 | Event | 1949 – Indonesian National Revolution: The Netherlands officially recognizes Indonesian independence. End of the Dutch East Indies. |
| 145712 | December 27 | Event | 1966 – The Cave of Swallows, the largest known cave shaft in the world, is discovered in Aquismón, San Luis Potosí, Mexico. |
| 145713 | December 27 | Event | 1968 – Apollo program: Apollo 8 splashes down in the Pacific Ocean, ending the first orbital manned mission to the Moon. |
| 145714 | December 27 | Event | 1978 – Spain becomes a democracy after 40 years of fascist dictatorship. |
| 145715 | December 27 | Event | 1979 – The Soviet Union invades the Democratic Republic of Afghanistan. |
| 145716 | December 27 | Event | 1983 – Pope John Paul II visits Mehmet Ali Ağca in Rebibbia's prison and personally forgives him for the 1981 attack on him in St. Peter's Square. |
| 145717 | December 27 | Event | 1985 – Palestinian guerrillas kill eighteen people inside the airports of Rome, Italy, and Vienna, Austria. |
| 145718 | December 27 | Event | 1989 – The Romanian Revolution concludes, as the last minor street confrontations and stray shootings abruptly end in the country's capital, Bucharest. |
| 145719 | December 27 | Event | 1996 – Taliban forces retake the strategic Bagram Airfield which solidifies their buffer zone around Kabul, Afghanistan. |
| 145720 | December 27 | Event | 1997 – Protestant paramilitary leader Billy Wright is assassinated in Northern Ireland, United Kingdom. |
| 145721 | December 27 | Event | 2001 – China is granted permanent normal trade relations with the United States. |
| 145722 | December 27 | Event | 2002 – Two truck bombs kill 72 and wound 200 at the pro-Moscow headquarters of the Chechen government in Grozny, Chechnya, Russia. |
| 145723 | December 27 | Event | 2004 – Radiation from an explosion on the magnetar SGR 1806-20 reaches Earth. It is the brightest extrasolar event known to have been witnessed on the planet. |
| 145724 | December 27 | Event | 2007 – Former Pakistani prime minister Benazir Bhutto is assassinated in a shooting incident. |
| 145725 | December 27 | Event | 2007 – Riots erupt in Mombasa, Kenya, after Mwai Kibaki is declared the winner of the presidential election, triggering a political, economic, and humanitarian crisis. |
| 145726 | December 27 | Event | 2008 – Operation Cast Lead: Israel launches 3-week operation on Gaza. |
| 145727 | December 27 | Event | 2009 – Iranian election protests: On the Day of Ashura in Tehran, Iran, government security forces fire upon demonstrators. |
| 145728 | December 27 | Birth | 1390 – Anne de Mortimer, Irish wife of Richard of Conisburgh, 3rd Earl of Cambridge (d. 1411) |
| 145729 | December 27 | Birth | 1571 – Johannes Kepler, German mathematician, astronomer, and astrologer (d. 1630) |
| 145730 | December 27 | Birth | 1572 – Johannes Vodnianus Campanus, Czech poet, playwright, and composer (d. 1622) |
| 145731 | December 27 | Birth | 1683 – Conyers Middleton, English clergyman and theologian (d. 1750) |
| 145732 | December 27 | Birth | 1714 – George Whitefield, English-American preacher and saint (d. 1770) |
| 145733 | December 27 | Birth | 1715 – Philippe de Noailles, French general (d. 1794) |
| 145734 | December 27 | Birth | 1721 – François Hemsterhuis, Dutch philosopher and author (d. 1790) |
| 145735 | December 27 | Birth | 1761 – Michael Andreas Barclay de Tolly, Russian field marshal and politician, Governor-General of Finland (d. 1818) |
| 145736 | December 27 | Birth | 1773 – George Cayley, English engineer and politician (d. 1857) |
| 145737 | December 27 | Birth | 1776 – Nikolay Kamensky, Russian general (d. 1811) |
| 145738 | December 27 | Birth | 1796 – Mirza Ghalib, Indian poet (d. 1869) |
| 145739 | December 27 | Birth | 1803 – François-Marie-Thomas Chevalier de Lorimier, Canadian activist (d. 1839) |
| 145740 | December 27 | Birth | 1809 – Alexandros Rizos Rangavis, Greek poet and politician, Foreign Minister of Greece (d. 1892) |