| 19951 | February 21 | Event | 1972 – The Soviet unmanned spaceship Luna 20 lands on the Moon. |
| 19952 | February 21 | Event | 1973 – Over the Sinai Desert, Israeli fighter aircraft shoot down Libyan Arab Airlines Flight 114 jet killing 108. |
| 19953 | February 21 | Event | 1974 – The last Israeli soldiers leave the west bank of the Suez Canal pursuant to a truce with Egypt. |
| 19954 | February 21 | Event | 1975 – Watergate scandal: Former United States Attorney General John N. Mitchell and former White House aides H. R. Haldeman and John Ehrlichman are sentenced to prison. |
| 19955 | February 21 | Event | 1995 – Steve Fossett lands in Leader, Saskatchewan, Canada becoming the first person to make a solo flight across the Pacific Ocean in a balloon. |
| 19956 | February 21 | Event | 2013 – At least 17 people are dead and 119 injured following several bombings in the Indian city of Hyderabad. |
| 19957 | February 21 | Birth | 1484 – Joachim I Nestor, Elector of Brandenburg (d. 1535) |
| 19958 | February 21 | Birth | 1556 – Sethus Calvisius, German astronomer, composer, and theorist (d. 1615) |
| 19959 | February 21 | Birth | 1621 – Rebecca Nurse, English-American victim of the Salem witch trials (d. 1692) |
| 19960 | February 21 | Birth | 1705 – Edward Hawke, 1st Baron Hawke, English admiral (d. 1781) |
| 19961 | February 21 | Birth | 1721 – John McKinly, Irish-American physician and politician, 1st Governor of Delaware (d. 1796) |
| 19962 | February 21 | Birth | 1723 – Louis-Pierre Anquetil, French historian and author (d. 1808) |
| 19963 | February 21 | Birth | 1728 – Peter III of Russia (d. 1762) |
| 19964 | February 21 | Birth | 1783 – Catharina of Württemberg (d. 1835) |
| 19965 | February 21 | Birth | 1791 – Carl Czerny, Austrian pianist and composer (d. 1857) |
| 19966 | February 21 | Birth | 1794 – Antonio López de Santa Anna, Mexican general and politician, 8th President of Mexico (d. 1876) |
| 19967 | February 21 | Birth | 1801 – John Henry Newman, English cardinal (d. 1890) |
| 19968 | February 21 | Birth | 1817 – José Zorrilla, Spanish poet and playwright (d. 1893) |
| 19969 | February 21 | Birth | 1821 – Charles Scribner I, American publisher, founded Charles Scribner's Sons (d. 1871) |
| 19970 | February 21 | Birth | 1836 – Léo Delibes, French pianist and composer (d. 1891) |
| 19971 | February 21 | Birth | 1844 – Charles-Marie Widor, French organist and composer (d. 1937) |
| 19972 | February 21 | Birth | 1860 – Karel Matěj Čapek-Chod, Czech journalist and author (d. 1927) |
| 19973 | February 21 | Birth | 1860 – Goscombe John, Welsh-English sculptor (d. 1952) |
| 19974 | February 21 | Birth | 1865 – John Haden Badley, English author and educator, founded the Bedales School (d. 1967) |
| 19975 | February 21 | Birth | 1867 – Otto Hermann Kahn, German banker and philanthropist (d. 1934) |
| 19976 | February 21 | Birth | 1875 – Jeanne Calment, French super-centenarian (d. 1997) |
| 19977 | February 21 | Birth | 1876 – Pyotr Konchalovsky, Russian painter (d. 1956) |
| 19978 | February 21 | Birth | 1878 – Mirra Alfassa, French-Indian spiritual leader (d. 1973) |
| 19979 | February 21 | Birth | 1880 – Waldemar Bonsels, German author (d. 1952) |
| 19980 | February 21 | Birth | 1885 – Sacha Guitry, Russian-French actor, director, and playwright (d. 1957) |