| 20041 | February 21 | Birth | 1948 – Bill Slayback, American baseball player and singer (d. 2015) |
| 20042 | February 21 | Birth | 1949 – Frank Brunner, American illustrator |
| 20043 | February 21 | Birth | 1949 – Jerry Harrison, American singer-songwriter, guitarist, and producer (Talking Heads and The Modern Lovers) |
| 20044 | February 21 | Birth | 1951 – Dos Caras, Mexican wrestler and actor |
| 20045 | February 21 | Birth | 1951 – Vince Welnick, American keyboard player (Grateful Dead, The Tubes, and Missing Man Formation) (d. 2006) |
| 20046 | February 21 | Birth | 1952 – Jean-Jacques Burnel, English bass player, songwriter, and producer (The Stranglers) |
| 20047 | February 21 | Birth | 1952 – Jeff Shaara, American author |
| 20048 | February 21 | Birth | 1953 – Christine Ebersole, American actress and singer |
| 20049 | February 21 | Birth | 1953 – William Petersen, American actor and producer |
| 20050 | February 21 | Birth | 1954 – Victor Martinez, Mexican-American author and poet (d. 2011) |
| 20051 | February 21 | Birth | 1954 – Mike Pickering, English DJ and saxophonist (Quando Quango and M People) |
| 20052 | February 21 | Birth | 1955 – Kelsey Grammer, American actor, singer, director, and producer |
| 20053 | February 21 | Birth | 1957 – Julia Benjamin, American actress |
| 20054 | February 21 | Birth | 1958 – Jake Burns, Irish singer-songwriter and guitarist (Stiff Little Fingers) |
| 20055 | February 21 | Birth | 1958 – Mary Chapin Carpenter, American singer-songwriter and guitarist |
| 20056 | February 21 | Birth | 1958 – Jack Coleman, American actor and screenwriter |
| 20057 | February 21 | Birth | 1958 – Alan Trammell, American baseball player and manager |
| 20058 | February 21 | Birth | 1959 – José María Cano, Spanish singer-songwriter and painter (Mecano) |
| 20059 | February 21 | Birth | 1960 – Plamen Oresharski, Bulgarian economist and politician, 52nd Prime Minister of Bulgaria |
| 20060 | February 21 | Birth | 1960 – Laurent Petitguillaume, French radio and television host |
| 20061 | February 21 | Birth | 1960 – Steve Wynn, American singer-songwriter (The Dream Syndicate and The Baseball Project) |
| 20062 | February 21 | Birth | 1961 – Christopher Atkins, American actor, producer, and screenwriter |
| 20063 | February 21 | Birth | 1961 – Martha Hackett, American actress |
| 20064 | February 21 | Birth | 1961 – Rhonda Sing, Canadian wrestler (d. 2001) |
| 20065 | February 21 | Birth | 1962 – Vanessa Feltz, English journalist and actress |
| 20066 | February 21 | Birth | 1962 – Chuck Palahniuk, American journalist and author |
| 20067 | February 21 | Birth | 1962 – David Foster Wallace, American author and academic (d. 2008) |
| 20068 | February 21 | Birth | 1963 – William Baldwin, American actor, producer, and screenwriter |
| 20069 | February 21 | Birth | 1964 – Mark Kelly, American captain, pilot, and astronaut |
| 20070 | February 21 | Birth | 1964 – Scott Kelly, American captain, pilot, and astronaut |