| 20161 | February 21 | Death | 1788 – Johann Georg Palitzsch, German astronomer and academic (b. 1723) |
| 20162 | February 21 | Death | 1821 – Georg Friedrich von Martens, German jurist and diplomat (b. 1756) |
| 20163 | February 21 | Death | 1824 – Eugène de Beauharnais, French general (b. 1781) |
| 20164 | February 21 | Death | 1846 – Emperor Ninkō of Japan (b. 1800) |
| 20165 | February 21 | Death | 1862 – Justinus Kerner, German poet and physician (b. 1786) |
| 20166 | February 21 | Death | 1891 – James Timberlake, American lieutenant and police officer (b. 1846) |
| 20167 | February 21 | Death | 1900 – Marthinus Nikolaas Ras, South African farmer, soldier, and gun maker (b. 1853) |
| 20168 | February 21 | Death | 1919 – Kurt Eisner, German journalist and politician, Minister-President of Bavaria (b. 1867) |
| 20169 | February 21 | Death | 1926 – Heike Kamerlingh Onnes, Dutch physicist and academic, Nobel Prize laureate (b. 1853) |
| 20170 | February 21 | Death | 1934 – Augusto César Sandino, Nicaraguan rebel leader (b. 1895) |
| 20171 | February 21 | Death | 1938 – George Ellery Hale, American astronomer and academic (b. 1868) |
| 20172 | February 21 | Death | 1941 – Frederick Banting, Canadian physician and academic, Nobel Prize laureate (b. 1891) |
| 20173 | February 21 | Death | 1944 – Ferenc Szisz, Hungarian-French race car driver (b. 1873) |
| 20174 | February 21 | Death | 1945 – Eric Liddell, Chinese-Scottish rugby player and runner (b. 1902) |
| 20175 | February 21 | Death | 1946 – José Streel, Belgian journalist (b. 1911) |
| 20176 | February 21 | Death | 1949 – Tan Malaka, Indonesian educator and activist (b. 1894) |
| 20177 | February 21 | Death | 1956 – Ray Smith, English cricketer (b. 1914) |
| 20178 | February 21 | Death | 1958 – Duncan Edwards, English footballer (b. 1936) |
| 20179 | February 21 | Death | 1960 – Jacques Becker, French director and screenwriter (b. 1906) |
| 20180 | February 21 | Death | 1965 – Malcolm X, American minister and activist (b. 1925) |
| 20181 | February 21 | Death | 1966 – Paul Comtois, Canadian politician, 21st Lieutenant Governor of Quebec (b. 1895) |
| 20182 | February 21 | Death | 1967 – Charles Beaumont, American author (b. 1929) |
| 20183 | February 21 | Death | 1968 – Howard Florey, Australian pathologist and pharmacologist, Nobel Prize laureate (b. 1898) |
| 20184 | February 21 | Death | 1972 – Zhang Guohua, Chinese general and politician (b. 1914) |
| 20185 | February 21 | Death | 1972 – Bronislava Nijinska, Polish-Russian dancer and choreographer (b. 1891) |
| 20186 | February 21 | Death | 1972 – Eugène Tisserant, French cardinal (b. 1884) |
| 20187 | February 21 | Death | 1974 – Tim Horton, Canadian ice hockey player and businessman, co-founded Tim Hortons (b. 1930) |
| 20188 | February 21 | Death | 1977 – Gerald Barry, English Army officer and cricketer (b. 1896) |
| 20189 | February 21 | Death | 1977 – Nolan Strong, American singer (Nolan Strong & the Diablos) (b. 1934) |
| 20190 | February 21 | Death | 1980 – Alfred Andersch, German-Swiss author (b. 1914) |