| 20401 | February 22 | Birth | 1950 – Miou-Miou, French actress |
| 20402 | February 22 | Birth | 1950 – Julius Erving, American basketball player and sportscaster |
| 20403 | February 22 | Birth | 1950 – Lenny Kuhr, Dutch singer-songwriter |
| 20404 | February 22 | Birth | 1950 – Genesis P-Orridge, English singer-songwriter (Psychic TV, Thee Majesty, Pigface, and Splinter Test) |
| 20405 | February 22 | Birth | 1950 – Julie Walters, English actress and singer |
| 20406 | February 22 | Birth | 1951 – Ellen Greene, American singer and actress |
| 20407 | February 22 | Birth | 1952 – Cyrinda Foxe, American model and actress (d. 2002) |
| 20408 | February 22 | Birth | 1952 – Bill Frist, American physician and politician |
| 20409 | February 22 | Birth | 1952 – Bernard Silverman, English minister, statistician, and academic |
| 20410 | February 22 | Birth | 1953 – Graham Lewis, English bass player (Wire and Dome) |
| 20411 | February 22 | Birth | 1953 – Nigel Planer, English actor and screenwriter |
| 20412 | February 22 | Birth | 1955 – David Axelrod, American journalist and political adviser |
| 20413 | February 22 | Birth | 1955 – Tim Young, Canadian ice hockey player |
| 20414 | February 22 | Birth | 1957 – Willie Smits, Dutch microbiologist and engineer |
| 20415 | February 22 | Birth | 1958 – Dave Spitz, American bass player and songwriter (Black Sabbath, White Lion, Great White, and Impellitteri) |
| 20416 | February 22 | Birth | 1959 – Jiří Čunek, Czech politician |
| 20417 | February 22 | Birth | 1959 – Kyle MacLachlan, American actor |
| 20418 | February 22 | Birth | 1960 – Thomas Galbraith, 2nd Baron Strathclyde, Scottish politician, Chancellor of the Duchy of Lancaster |
| 20419 | February 22 | Birth | 1961 – Akira Takasaki, Japanese guitarist, songwriter, and producer (Lazy and Loudness) |
| 20420 | February 22 | Birth | 1962 – Steve Irwin, Australian zoologist and television host (d. 2006) |
| 20421 | February 22 | Birth | 1963 – Vijay Singh, Fijian-American golfer |
| 20422 | February 22 | Birth | 1964 – Ed Boon, American video game designer, co-created Mortal Kombat |
| 20423 | February 22 | Birth | 1964 – Gigi Fernández, Puerto Rican-American tennis player |
| 20424 | February 22 | Birth | 1965 – Chris Dudley, American basketball player and politician |
| 20425 | February 22 | Birth | 1965 – Kieren Fallon, Irish jockey |
| 20426 | February 22 | Birth | 1965 – Pat LaFontaine, American ice hockey player |
| 20427 | February 22 | Birth | 1966 – Rachel Dratch, American actress and singer |
| 20428 | February 22 | Birth | 1966 – Thorsten Kaye, German actor |
| 20429 | February 22 | Birth | 1966 – Aiden Shaw, English porn actor and singer |
| 20430 | February 22 | Birth | 1967 – Psicosis II, Mexican wrestler |