| 22111 | February 27 | Event | 1943 – The Rosenstrasse protest starts in Berlin. |
| 22112 | February 27 | Event | 1951 – The Twenty-second Amendment to the United States Constitution, limiting Presidents to two terms, is ratified. |
| 22113 | February 27 | Event | 1955 – Soviet Union regional elections, 1955. |
| 22114 | February 27 | Event | 1961 – The first congress of the Spanish Trade Union Organisation is inaugurated. |
| 22115 | February 27 | Event | 1962 – Two dissident Vietnam Air Force pilots bomb the Independence Palace in Saigon in a failed attempt to assassinate South Vietnam President Ngô Đình Diệm. |
| 22116 | February 27 | Event | 1963 – The Dominican Republic receives its first democratically elected president, Juan Bosch, since the end of the dictatorship led by Rafael Trujillo. |
| 22117 | February 27 | Event | 1964 – The Government of Italy asks for help to keep the Leaning Tower of Pisa from toppling over. |
| 22118 | February 27 | Event | 1971 – Doctors in the first Dutch abortion clinic (the Mildredhuis in Arnhem) start to perform aborti provocati. |
| 22119 | February 27 | Event | 1973 – The American Indian Movement (AIM) occupies Wounded Knee, South Dakota. |
| 22120 | February 27 | Event | 1976 – The formerly Spanish territory of Western Sahara, under the auspices of the Polisario Front declares independence as the Sahrawi Arab Democratic Republic. |
| 22121 | February 27 | Event | 1986 – The United States Senate allows its debates to be televised on a trial basis. |
| 22122 | February 27 | Event | 1988 – Sumgait pogrom: The Armenian community of Sumgait in Azerbaijan is targeted in a violent massacre. |
| 22123 | February 27 | Event | 1989 – Venezuela is rocked by the Caracazo riots. |
| 22124 | February 27 | Event | 1991 – Gulf War: U.S. President George H. W. Bush announces that "Kuwait is liberated". |
| 22125 | February 27 | Event | 1995 – Zakho: A terrorist explosion in a market in the city of Zakho leaves about 100 dead and 150 wounded. |
| 22126 | February 27 | Event | 2002 – Ryanair Flight 296 catches fire at London Stansted Airport. Subsequent investigations criticize Ryanair's handling of the evacuation. |
| 22127 | February 27 | Event | 2002 – Godhra train burning: A Muslim mob torches a train returning from Ayodhya, killing 59 Hindu pilgrims. |
| 22128 | February 27 | Event | 2004 – A bombing of a Superferry by Abu Sayyaf in the Philippines' worst terrorist attack kills 116. |
| 22129 | February 27 | Event | 2004 – The initial version of the John Jay Report, with details about the Catholic sexual abuse scandal in the United States, is released. |
| 22130 | February 27 | Event | 2007 – The Chinese Correction: The Shanghai Stock Exchange falls 9%, the largest drop in ten years. |
| 22131 | February 27 | Event | 2010 – An earthquake measuring 8.8 on the Richter scale strikes central parts of Chile leaving over 500 victims, and thousands injured. The quake triggered a tsunami which struck Hawaii shortly after. |
| 22132 | February 27 | Event | 2012 – A section of a nine-story apartment building in the city of Astrakhan, Russia, collapses in a natural gas explosion, killing ten people and injuring at least 12 others. |
| 22133 | February 27 | Event | 2013 – At least 19 people are killed when a fire breaks out at an illegal market in Kolkata, India. |
| 22134 | February 27 | Event | 2013 – Five people (including the perpetrator) are killed and five others injured in a shooting at a factory in Menznau, Switzerland. |
| 22135 | February 27 | Event | 2015 – A gunman kills seven people then himself in a series of shootings in Tyrone, Missouri. |
| 22136 | February 27 | Birth | 272 – Constantine the Great, Roman emperor (d. 337) |
| 22137 | February 27 | Birth | 1572 – Francis II, Duke of Lorraine (d. 1632) |
| 22138 | February 27 | Birth | 1575 – John Adolf, Duke of Holstein-Gottorp (d. 1616) |
| 22139 | February 27 | Birth | 1606 – Laurent de La Hyre, French painter (d. 1656) |
| 22140 | February 27 | Birth | 1630 – Roche Braziliano, Dutch pirate (d. 1671) |