| 22921 | February 28 | Holiday and observance | Rare Disease Day (last day of February) |
| 22922 | February 29 | Event | 1504 – Christopher Columbus uses his knowledge of a lunar eclipse that night to convince Native Americans to provide him with supplies. |
| 22923 | February 29 | Event | 1644 – Abel Tasman's second Pacific voyage began. |
| 22924 | February 29 | Event | 1704 – Queen Anne's War: French forces and Native Americans stage a raid on Deerfield, Massachusetts, killing 56 villagers and taking more than 100 captive. |
| 22925 | February 29 | Event | 1712 – February 29 is followed by February 30 in Sweden, in a move to abolish the Swedish calendar for a return to the Old style. |
| 22926 | February 29 | Event | 1720 – Queen Ulrika Eleonora of Sweden abdicates in favour of her husband, who becomes King Frederick I on 24 March. |
| 22927 | February 29 | Event | 1752 – King Alaungpaya founds Konbaung Dynasty, the last dynasty of Burmese monarchy. |
| 22928 | February 29 | Event | 1768 – Polish nobles formed Bar Confederation. |
| 22929 | February 29 | Event | 1796 – The Jay Treaty between the United States and Great Britain comes into force, facilitating ten years of peaceful trade between the two nations. |
| 22930 | February 29 | Event | 1864 – American Civil War: Kilpatrick-Dahlgren Raid fails – plans to free 15,000 Union soldiers being held near Richmond, Virginia are thwarted. |
| 22931 | February 29 | Event | 1892 – St. Petersburg, Florida is incorporated. |
| 22932 | February 29 | Event | 1912 – The Piedra Movediza (Moving Stone) of Tandil falls and breaks. |
| 22933 | February 29 | Event | 1916 – Tokelau is annexed by the United Kingdom. |
| 22934 | February 29 | Event | 1916 – Child labor: In South Carolina, the minimum working age for factory, mill, and mine workers is raised from twelve to fourteen years old. |
| 22935 | February 29 | Event | 1920 – Czechoslovak National assembly adopted the Constitution. |
| 22936 | February 29 | Event | 1936 – Baby Snooks, played by Fanny Brice, debuts on the radio program The Ziegfeld Follies of the Air. |
| 22937 | February 29 | Event | 1936 – February 26 Incident in Tokyo ends. |
| 22938 | February 29 | Event | 1940 – For her role as Mammy in Gone with the Wind, Hattie McDaniel becomes the first African American to win an Academy Award. |
| 22939 | February 29 | Event | 1940 – Finland initiates Winter War peace negotiations. |
| 22940 | February 29 | Event | 1940 – In a ceremony held in Berkeley, California, because of the war, physicist Ernest Lawrence receives the 1939 Nobel Prize in Physics from Sweden's Consul General in San Francisco. |
| 22941 | February 29 | Event | 1944 – World War II: The Admiralty Islands are invaded in Operation Brewer led by American General Douglas MacArthur. |
| 22942 | February 29 | Event | 1952 – The island of Heligoland is restored to German authority. |
| 22943 | February 29 | Event | 1960 – An earthquake in Morocco kills over 3,000 people and nearly destroys Agadir in the southern part of the country. |
| 22944 | February 29 | Event | 1964 – In Sydney, Australian swimmer Dawn Fraser sets a new world record in the 100-meter freestyle swimming competition (58.9 seconds). |
| 22945 | February 29 | Event | 1972 – Vietnam War: Vietnamization – South Korea withdraws 11,000 of its 48,000 troops from Vietnam. |
| 22946 | February 29 | Event | 1980 – Gordie Howe of the then Hartford Whalers makes NHL history as he scores his 800th goal. |
| 22947 | February 29 | Event | 1988 – South African archbishop Desmond Tutu is arrested along with 100 clergymen during a five-day anti-apartheid demonstration in Cape Town. |
| 22948 | February 29 | Event | 1988 – Svend Robinson becomes the first member of the Canadian House of Commons to come out as gay. |
| 22949 | February 29 | Event | 1992 – First day of Bosnia and Herzegovina independence referendum. |
| 22950 | February 29 | Event | 1996 – Faucett Flight 251 crashes in the Andes, all 123 passengers and crew died. |