| 130321 | November 16 | Event | 1491 – An auto-da-fé, held in the Brasero de la Dehesa outside of Ávila, concludes the case of the Holy Child of La Guardia with the public execution of several Jewish and converso suspects. |
| 130322 | November 16 | Event | 1532 – Francisco Pizarro and his men capture Inca Emperor Atahualpa at the Battle of Cajamarca. |
| 130323 | November 16 | Event | 1632 – Thirty Years' War: Battle of Lützen is fought, the Swedes are victorious but King Gustavus Adolphus of Sweden dies in the battle. |
| 130324 | November 16 | Event | 1776 – American Revolutionary War: British and Hessian units capture Fort Washington from the Patriots. |
| 130325 | November 16 | Event | 1776 – American Revolution: The United Provinces (Low Countries) recognize the independence of the United States. |
| 130326 | November 16 | Event | 1793 – French Revolution: Ninety anti-republican Catholic priests are executed by drowning at Nantes. |
| 130327 | November 16 | Event | 1797 – The Prussian heir apparent, Frederick William, becomes King of Prussia as Frederick William III. |
| 130328 | November 16 | Event | 1805 – Napoleonic Wars: Battle of Schöngrabern – Russian forces under Pyotr Bagration delay the pursuit by French troops under Joachim Murat. |
| 130329 | November 16 | Event | 1822 – American Old West: Missouri trader William Becknell arrives in Santa Fe, New Mexico, over a route that became known as the Santa Fe Trail. |
| 130330 | November 16 | Event | 1828 – Greek War of Independence: The London Protocol entails the creation of an autonomous Greek state under Ottoman suzerainty, encompassing the Morea and the Cyclades. |
| 130331 | November 16 | Event | 1849 – A Russian court sentences writer Fyodor Dostoyevsky to death for anti-government activities linked to a radical intellectual group his sentence is later commuted to hard labor. |
| 130332 | November 16 | Event | 1852 – The English astronomer John Russell Hind discovers the asteroid 22 Kalliope. |
| 130333 | November 16 | Event | 1857 – Second relief of Lucknow – twenty-four Victoria Crosses are awarded, the most in a single day. |
| 130334 | November 16 | Event | 1863 – American Civil War: Battle of Campbell's Station near Knoxville, Tennessee – Confederate troops unsuccessfully attack Union forces. |
| 130335 | November 16 | Event | 1885 – Canadian rebel leader of the Métis and "Father of Manitoba" Louis Riel is executed for treason. |
| 130336 | November 16 | Event | 1904 – English engineer John Ambrose Fleming receives a patent for the thermionic valve (vacuum tube). |
| 130337 | November 16 | Event | 1907 – Indian Territory and Oklahoma Territory join to form Oklahoma, which is admitted as the 46th U.S. state. |
| 130338 | November 16 | Event | 1907 – Cunard Line's RMS Mauretania, sister ship of RMS Lusitania, sets sail on her maiden voyage from Liverpool, England, to New York City. |
| 130339 | November 16 | Event | 1914 – The Federal Reserve Bank of the United States officially opens. |
| 130340 | November 16 | Event | 1920 – Qantas, Australia's national airline, is founded as Queensland and Northern Territory Aerial Services Limited. |
| 130341 | November 16 | Event | 1940 – World War II: In response to the leveling of Coventry by the German Luftwaffe two days before, the Royal Air Force bombs Hamburg. |
| 130342 | November 16 | Event | 1940 – Holocaust: In occupied Poland, the Nazis close off the Warsaw Ghetto from the outside world. |
| 130343 | November 16 | Event | 1940 – New York City's "Mad Bomber" George Metesky places his first bomb at a Manhattan office building used by Consolidated Edison. |
| 130344 | November 16 | Event | 1943 – World War II: American bombers strike a hydro-electric power facility and heavy water factory in German-controlled Vemork, Norway. |
| 130345 | November 16 | Event | 1944 – World War II: Operation Queen, the costly Allied thrust to the Rur, is launched. |
| 130346 | November 16 | Event | 1944 – World War II: Dueren, Germany, is destroyed by Allied bombers. |
| 130347 | November 16 | Event | 1945 – UNESCO is founded. |
| 130348 | November 16 | Event | 1965 – Venera program: The Soviet Union launches the Venera 3 space probe toward Venus, which will be the first spacecraft to reach the surface of another planet. |
| 130349 | November 16 | Event | 1973 – Skylab program: NASA launches Skylab 4 with a crew of three astronauts from Cape Canaveral, Florida for an 84-day mission. |
| 130350 | November 16 | Event | 1973 – U.S. President Richard Nixon signs the Trans-Alaska Pipeline Authorization Act into law, authorizing the construction of the Alaska Pipeline. |